SURVIVAL OF SPIRAL GANGLION-CELLS IN PROFOUND SENSORINEURAL HEARING-LOSS - IMPLICATIONS FOR COCHLEAR IMPLANTATION
SURVIVAL OF SPIRAL GANGLION-CELLS IN PROFOUND SENSORINEURAL HEARING-LOSS - IMPLICATIONS FOR COCHLEAR IMPLANTATION
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DOI：
10.1177/000348948909800602
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发表时间：
1989-06-01
影响因子：
1.4
通讯作者：
GLYNN, RJ
中科院分区：
文献类型：
--
作者：
NADOL, JB;YOUNG, YS;GLYNN, RJ
对66例终生严重耳聋患者的93块颞骨进行了系列光镜切片重建。分析螺旋神经节细胞总数、节段性螺旋神经节细胞计数与年龄、听力损失病程、听力损失原因的相关性。双变量分析显示老年耳聋患者螺旋神经节细胞总数较年轻耳聋患者低，且随着听力损失和全聋持续时间的延长而降低。然而，多元回归分析表明，听力损失的原因是螺旋神经节细胞总数的唯一最重要的决定因素。氨基糖苷类毒性耳聋或突发性特发性耳聋患者残留螺旋神经节细胞数最高，推测为病毒性迷路炎、细菌性迷路炎、先天性或遗传性耳聋的患者残留螺旋神经节细胞数最低。
Ninety-three temporal bones from 66 patients who were profoundly deaf during life were reconstructed by analysis of serial light microscopic sections. The correlations of total and segmental spiral ganglion cell counts with age, duration of hearing loss and profound deafness, and cause of hearing loss were evaluated. Bivariate analysis demonstrated that total spiral ganglion cell count tended to be lower in older than in younger deaf individuals and lower with longer duration of hearing loss and total deafness. However, multiple regression analysis demonstrated that the cause of hearing loss was the single most significant determinant of total spiral ganglion cell count. Patients with deafness due to aminoglycoside toxicity or sudden idiopathic deafness had the highest residual spiral ganglion cell count and patients with deafness due to presumptive postnatal viral labyrinthitis, bacterial labyrinthitis, and congenital or genetic causes had the lowest numbers of residual spiral ganglion cells.