The Sealing Zone in Osteoclasts: A Self-Organized Structure on the Bone.
The Sealing Zone in Osteoclasts: A Self-Organized Structure on the Bone.
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DOI：
10.3390/ijms19040984
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发表时间：
2018-03-26
影响因子：
5.6
通讯作者：
Nakamura M
中科院分区：
文献类型：
--
作者：
Takito J;Inoue S;Nakamura M
破骨细胞在骨吸收过程中形成一种特殊的细胞-基质粘附结构，称为“密封区”。密封区是一个动态的富含肌动蛋白的结构，它限定了骨的吸收区域。密封带的详细动力学和精细结构一直难以捉摸。玻璃上的破骨细胞不会形成封闭区，但会产生一个单独的超分子结构，称为“podosome带”。Podosomes是基于整合素的粘附复合物，参与基质粘附、细胞迁移、基质降解和机械传感。侵袭伪足是癌细胞中的伪足样突起，通过促进基质降解参与细胞侵入其他组织。在成熟过程中，足体和侵入足都表现出肌动蛋白模式的转变。我们以前发现，Arp 2/3依赖的肌动蛋白流发生在所有观察到的组装模式的破骨细胞的破骨细胞。已知网骨藻细胞中的肌动蛋白波在其进化过程中表现出类似的模式转变。由于显着的进步，在我们的理解有关的机制，足体/invadopodia形成在过去的十年中，我们重新审视了密封区的结构和功能，在这篇评论中，强调可能参与的自组织肌动蛋白波的器官发生的密封区。
Osteoclasts form a specialized cell–matrix adhesion structure, known as the “sealing zone”, during bone resorption. The sealing zone is a dynamic actin-rich structure that defines the resorption area of the bone. The detailed dynamics and fine structure of the sealing zone have been elusive. Osteoclasts plated on glass do not form a sealing zone, but generate a separate supra-molecular structure called the “podosome belt”. Podosomes are integrin-based adhesion complexes involved in matrix adhesion, cell migration, matrix degradation, and mechanosensing. Invadopodia, podosome-like protrusions in cancer cells, are involved in cell invasion into other tissues by promoting matrix degradation. Both podosomes and invadopodia exhibit actin pattern transitions during maturation. We previously found that Arp2/3-dependent actin flow occurs in all observed assembly patterns of podosomes in osteoclasts on glass. It is known that the actin wave in Dictyostelium cells exhibits a similar pattern transition in its evolution. Because of significant advances in our understanding regarding the mechanism of podosomes/invadopodia formation over the last decade, we revisited the structure and function of the sealing zone in this review, highlighting the possible involvement of self-organized actin waves in the organogenesis of the sealing zone.
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DOI：
10.1083/jcb.148.4.665
发表时间：
2000-02-21
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chellaiah M;Kizer N;Silva M;Alvarez U;Kwiatkowski D;Hruska KA
通讯作者：
Hruska KA
影响因子：
9.2
作者：
Collin, Olivier;Na, Sungsoo;Chowdhury, Farhan;Hong, Michael;Shin, Myung Eun;Wang, Fei;Wang, Ning
通讯作者：
Wang, Ning
影响因子：
20.3
作者：
Calle, Y;Jones, GE;Thrasher, AJ
通讯作者：
Thrasher, AJ
影响因子：
3.3
作者：
Destaing, O;Saltel, F;Bard, F
通讯作者：
Bard, F
影响因子：
3.3
作者：
Chabadel, Anne;Banon-Rodriguez, Inmaculada;Saltel, Frederic
通讯作者：
Saltel, Frederic