Compromised Blood-Brain Barrier Integrity Is Associated With Total Magnetic Resonance Imaging Burden of Cerebral Small Vessel Disease.
Compromised Blood-Brain Barrier Integrity Is Associated With Total Magnetic Resonance Imaging Burden of Cerebral Small Vessel Disease.
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DOI：
10.3389/fneur.2018.00221
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发表时间：
2018
影响因子：
3.4
通讯作者：
Hu W
中科院分区：
文献类型：
--
作者：
Li Y;Li M;Zuo L;Shi Q;Qin W;Yang L;Jiang T;Hu W
一些研究表明，血脑屏障（BBB）完整性受损可能在个体脑小血管疾病（cSVD）标志物的发病机制中起关键作用，但血脑屏障通透性与总磁共振成像（MRI） cSVD负担之间的关系尚不清楚。本研究旨在探讨血脑屏障通透性与MRI cSVD总负荷的关系。没有症状性卒中病史的连续参与者被纳入了这项横断面研究。凹窝、白质高信号（WMH）、脑微出血和血管周围间隙扩大的存在以顺序评分（范围0-4）记录。我们使用动态对比增强mri和Patlak药代动力学模型来量化正常白质（NAWM）、WMH、皮质灰质（CGM）和深部灰质（DGM）的血脑屏障通透性。所有99名参与者的平均年龄为70.33岁（49-90岁）。经年龄、性别和血管危险因素校正后的多变量线性回归分析显示，NAWM、WMH、CGM和DGM的渗漏率和渗漏曲线下面积与MRI总cSVD负担呈正相关（P < 0.01）。此外，NAWM、CGM和DGM的血浆体积分数与MRI cSVD总负荷呈负相关（均P < 0.05）。本研究证实血脑屏障完整性受损与MRI总cSVD负荷相关，提示血脑屏障功能障碍可能是cSVD发病的关键因素。需要进行纵向研究来确定血脑屏障通透性与MRI cSVD总负荷之间是否存在因果关系。
Several studies have demonstrated that compromised blood–brain barrier (BBB) integrity may play a pivotal role in the pathogenesis of individual cerebral small vessel disease (cSVD) markers, but the association between BBB permeability and total magnetic resonance imaging (MRI) cSVD burden remains unclear. This study aimed to investigate the relationship between BBB permeability and total MRI cSVD burden. Consecutive participants without symptomatic stroke history presented for physical examination were enrolled in this cross-sectional study. The presence of lacunes, white matter hyperintensities (WMH), cerebral microbleeds, and enlarged perivascular spaces was recorded in an ordinal score (range 0–4). We used dynamic contrast-enhanced-MRI and Patlak pharmacokinetic model to quantify BBB permeability in the normal-appearing white matter (NAWM), WMH, cortical gray matter (CGM), and deep gray matter (DGM). All 99 participants averaged 70.33 years old (49–90 years). Multivariable linear regression analyses adjusted for age, sex, and vascular risk factors showed that leakage rate and area under the leakage curve in the NAWM, WMH, CGM, and DGM were positively associated with total MRI cSVD burden (all P < 0.01). Moreover, fractional blood plasma volumes in the NAWM, CGM, and DGM were negatively associated with total MRI cSVD burden (all P < 0.05). This study verified that compromised BBB integrity is associated with total MRI cSVD burden, suggesting that BBB dysfunction may be a critical contributor to the pathogenesis of cSVD. Longitudinal studies are required to determine whether there is a causal relationship between BBB permeability and total MRI cSVD burden.
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影响因子：
3.8
作者：
van de Haar, Harm J.;Jansen, Jacobus F. A.;Backes, Walter H.
通讯作者：
Backes, Walter H.
影响因子：
4.2
作者：
Cramer, S. P.;Simonsen, H.;Frederiksen, J. L.;Rostrup, E.;Larsson, H. B. W.
通讯作者：
Larsson, H. B. W.
影响因子：
8.3
作者：
Mueller, Kristin;Courtois, Gilles;Schwaninger, Markus
通讯作者：
Schwaninger, Markus
影响因子：
8.3
作者：
Wardlaw JM;Doubal FN;Valdes-Hernandez M;Wang X;Chappell FM;Shuler K;Armitage PA;Carpenter TC;Dennis MS
通讯作者：
Dennis MS
DOI：
10.1186/2040-7378-5-4
发表时间：
2013-03-14
期刊：
Experimental & translational stroke medicine
影响因子：
--
作者：
Schreiber S;Bueche CZ;Garz C;Braun H
通讯作者：
Braun H