CIRCADIAN-RHYTHM IN SERUM PARATHYROID-HORMONE CONCENTRATION IN HUMAN SUBJECTS - CORRELATION WITH SERUM-CALCIUM, PHOSPHATE, ALBUMIN, AND GROWTH-HORMONE LEVELS
CIRCADIAN-RHYTHM IN SERUM PARATHYROID-HORMONE CONCENTRATION IN HUMAN SUBJECTS - CORRELATION WITH SERUM-CALCIUM, PHOSPHATE, ALBUMIN, AND GROWTH-HORMONE LEVELS
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DOI：
10.1172/jci107010
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发表时间：
1972-01-01
影响因子：
15.9
通讯作者：
CANTERBU.JM
中科院分区：
文献类型：
--
作者：
JUBIZ, W;TYLER, FH;CANTERBU.JM
正常人血清钙、白蛋白和甲状旁腺素浓度的昼夜变化已被证实。这三种血液成分的水平在白天非常稳定，但在夜间和清晨发生了显著变化。血清钙水平在晚上8：00最高，在凌晨2：00和4：00之间达到最低点。血清白蛋白水平与血清钙水平平行。甲状旁腺激素水平在晚上8点后开始上升，在凌晨2点到4点之间达到最高水平，到上午8：00下降到基线值。夜间血清钙水平下降似乎是继发于血容量增加导致血清蛋白稀释。夜间PTH水平的升高似乎与正常范围内的血清钙水平无关，但可被诱导的高钙血症所消除。血清磷水平在上午8：00至10：00之间最低，在上午2：00至4：00之间最高。这些数据表明，血清磷水平的昼夜变化不受甲状旁腺激素的影响，但当甲状旁腺激素的分泌受到抑制时，这种变化会被夸大。它们独立于生长激素水平和活性，但在长时间禁食期间会发生很大变化。
A circadian variation in serum calcium, albumin and PTH concentration in normal subjects has been demonstrated. The levels of the three blood constituents were remarkably constant during the day, but striking night and early morning changes occurred. Serum calcium levels were highest at 8:00 p.m. and reached a nadir between 2:00 and 4:00 a.m. Serum albumin levels were parallel to those of serum calcium. PTH levels began to rise after 8:00 p.m., reached the highest levels between 2:00 and 4:00 a.m., and fell to baseline values by 8:00 a.m. The nocturnal fall in serum calcium levels appears to be secondary to dilution of serum proteins by increasing blood volume. The nocturnal rise in PTH levels appears to be independent of serum calcium levels within the normal range but it can be abolished by induced hypercalcemia.Serum phosphate levels were lowest between 8:00 a.m. and 10:00 a.m. and highest between 2:00 a.m. and 4:00 a.m. The data presented suggest that circadian changes in serum phosphate levels are not mediatedin totoby parathyroid hormone but they are exaggerated when the secretion of this hormone is inhibited. They are independent of growth hormone levels and activity but they are greatly modified during a prolonged fast.