Molecular mechanisms underlying the corneal endothelial pump.
Molecular mechanisms underlying the corneal endothelial pump.
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DOI：
10.1016/j.exer.2011.06.004
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发表时间：
2012-02
影响因子：
3.4
通讯作者：
Bonanno, Joseph A.
中科院分区：
文献类型：
--
作者：
Bonanno, Joseph A.
角膜内皮负责维持角膜的水合作用。这是通过“泵-漏”机制实现的，其中内皮的主动转运特性代表“泵”，基质膨胀压力代表“漏”。对于“泵”，需要Na+，K+ ATP酶活性以及HCO 3 −，Cl−和碳酸酐酶活性的存在。已经鉴定了几种基底外侧（基质侧）阴离子转运蛋白、顶端（面向房水）离子通道和水通道，其可以支持离子分泌模型作为内皮泵的基础，然而缺乏持续阴离子通量、渗透梯度或对水通道的需要的证据。这促使考虑其他模型，如电渗透，并考虑代谢物通量作为内皮泵的组成部分。虽然支持“泵”的条件是已知的，但内皮“泵”的完整模型尚未出现。
The corneal endothelium is responsible for maintaining the hydration of the cornea. This is through a “Pump-Leak” mechanism where the active transport properties of the endothelium represent the “Pump” and the stromal swelling pressure represents the “Leak”. For the “Pump”, Na+,K+ ATPase activity and the presence of HCO3−, Cl−,and carbonic anhydrase activity are required. Several basolateral (stromal side) anion transporters, apical (facing the aqueous humor) ion channels and water channels have been identified that could support a model for ion secretion as the basis for the endothelial pump, however evidence of sustained anion fluxes, osmotic gradients or the need for water channels is lacking. This has prompted consideration of other models, such as Electro-osmosis, and consideration of metabolite flux as components of the endothelial pump. Although the conditions under which the “Pump” is supported are known, a complete model of the endothelial “Pump” has yet to emerge.
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