A model for mechanics of primary lymphatic valves.
A model for mechanics of primary lymphatic valves.
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DOI：
10.1115/1.1568128
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发表时间：
2003-06
期刊：
影响因子：
--
通讯作者：
E. Mendoza;G. Schmid-Schönbein
中科院分区：
文献类型：
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作者：
E. Mendoza;G. Schmid-Schönbein
最近的实验证据表明，淋巴管有两个瓣膜系统，一组位于初始淋巴管内皮细胞壁的初级瓣膜和一组位于淋巴管腔的次级瓣膜系统。虽然淋巴内继发性瓣膜有很好的描述，但没有对主要瓣膜的分析。我们提出了淋巴内皮细胞连接处原发性淋巴管瓣膜的模型。该模型由初始淋巴管细胞连接处的两个重叠内皮延伸组成。一个细胞延伸牢固地附着在相邻的结缔组织上，而另一个细胞延伸不附着在间质胶原上。当淋巴管压力低于相邻间质液压力时，淋巴管可自由弯曲进入淋巴管腔。因此，细胞连接处打开一个间隙，允许间质液进入淋巴管腔。当淋巴液压力高于相邻间质液压力时，内皮延伸相互接触，连接处关闭，防止液体回流到间质空间。该模型阐明了阀门作用的机制，并首次对初始淋巴管中液体收集和微循环中淋巴运输的机制进行了合理的分析。
Recent experimental evidence indicates that lymphatics have two valve systems, a set of primary valves in the wall of the endothelial cells of initial lymphatics and a secondary valve system in the lumen of the lymphatics. While the intralymphatic secondary valves are well described, no analysis of the primary valves is available. We propose a model for primary lymphatics valves at the junctions between lymphatic endothelial cells. The model consists of two overlapping endothelial extensions at a cell junction in the initial lymphatics. One cell extension is firmly attached to the adjacent connective tissue while the other cell extension is not attached to the interstitial collagen. It is free to bend into the lumen of the lymphatic when the lymphatic pressure falls below the adjacent interstitial fluid pressure. Thereby the cell junction opens a gap permitting entry of interstitial fluid into the lymphatic lumen. When the lymphatic fluid pressure rises above the adjacent interstitial fluid pressure, the endothelial extensions contact each other and the junction is closed preventing fluid reflow into the interstitial space. The model illustrates the mechanics of valve action and provides the first time a rational analysis of the mechanisms underlying fluid collection in the initial lymphatics and lymph transport in the microcirculation.