Increased mu-opioid receptor expression is associated with reduced disease-free and overall survival in laryngeal squamous cell carcinoma
Increased mu-opioid receptor expression is associated with reduced disease-free and overall survival in laryngeal squamous cell carcinoma
复制标题
mu-阿片受体表达增加与喉鳞状细胞癌无病生存率和总生存率降低相关
DOI：
10.1016/j.bja.2020.07.051
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发表时间：
2020-11-01
影响因子：
9.8
通讯作者：
Miao, Changhong
中科院分区：
文献类型：
--
作者：
Zhang, Hao;Sun, Minli;Miao, Changhong
背景：μ-阿片受体（莫尔）的表达与各种类型癌症的不良长期结局相关。莫尔的表达和喉鳞状细胞癌（LSCC）的临床结果之间的关联尚不清楚。方法：这项回顾性研究包括谁接受喉切除术的LSCC患者。测量肿瘤和相应邻近非癌标本中莫尔蛋白和OPRM 1基因的表达模式。倾向评分匹配用于最小化偏倚。主要终点为总生存期（OS）和无病生存期（DFS）。次要终点是术中舒芬太尼的消耗，手术并发症的等级根据Clavien-Dindo分类，和住院longs.Results：共207例喉鳞状细胞癌患者参加。倾向评分匹配后，在高莫尔表达患者中，1年、3年和5年时两组间DFS存在显著差异（分别为60.2% vs 81.2%，P=0.019; 39.4% vs 50.2%，P=0.026; 37.5% vs 42.5%，P=0.023）。高莫尔表达组的1、3和5年OS率显著较低（81.2% vs 93.2%，P=0.027; 57.7% vs 78.3%，P
Background: Expression of the mu-opioid receptor (MOR) is associated with poor long-term outcomes in various types of cancer. The association between MOR expression and clinical outcomes in laryngeal squamous cell carcinoma (LSCC) is not clear.Methods: This retrospective study included patients who underwent laryngectomy for LSCC. The expression pattern of the MOR protein and OPRM1 gene in tumours and corresponding adjacent non-carcinoma specimens was measured. Propensity score matching was used to minimise bias. The primary endpoints were overall survival (OS) and disease-free survival (DFS). The secondary endpoints were intraoperative sufentanil consumption, grade of surgical complications according to the Clavien-Dindo classification, and hospital length of stay.Results: A total of 207 LSCC patients were enrolled. After propensity score matching, there was a significant difference in DFS between groups at 1, 3, and 5 yr (60.2% vs 81.2%, P=0.019; 39.4% vs 50.2%, P=0.026; 37.5% vs 42.5%, P=0.023, respectively) in patients with high MOR expression. The OS rates at 1, 3, and 5 yr were significantly lower in the high MOR expression group (81.2% vs 93.2%, P=0.027; 57.7% vs 78.3%, P