Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
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DOI：
10.1038/ng.2802
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发表时间：
2013-12
期刊：
影响因子：
30.8
通讯作者：
Amouyel, Philippe
中科院分区：
文献类型：
--
作者：
Lambert, Jean-Charles;Ibrahim-Verbaas, Carla A.;Harold, Denise;Naj, Adam C.;Sims, Rebecca;Bellenguez, Celine;Jun, Gyungah;DeStefano, Anita L.;Bis, Joshua C.;Beecham, Gary W.;Grenier-Boley, Benjamin;Russo, Giancarlo;Thornton-Wells, Tricia A.;Jones, Nicola;Smith, Albert V.;Chouraki, Vincent;Thomas, Charlene;Ikram, M. Arfan;Zelenika, Diana;Vardarajan, Badri N.;Kamatani, Yoichiro;Lin, Chiao-Feng;Gerrish, Amy;Schmidt, Helena;Kunkle, Brian;Dunstan, Melanie L.;Ruiz, Agustin;Bihoreau, Marie-Therese;Choi, Seung-Hoan;Reitz, Christiane;Pasquier, Florence;Hollingworth, Paul;Ramirez, Alfredo;Hanon, Olivier;Fitzpatrick, Annette L.;Buxbaum, Joseph D.;Campion, Dominique;Crane, Paul K.;Baldwin, Clinton;Becker, Tim;Gudnason, Vilmundur;Cruchaga, Carlos;Craig, David;Amin, Najaf;Berr, Claudine;Lopez, Oscar L.;De Jager, Philip L.;Deramecourt, Vincent;Johnston, Janet A.;Evans, Denis;Lovestone, Simon;Letenneur, Luc;Moron, Francisco J.;Rubinsztein, David C.;Eiriksdottir, Gudny;Sleegers, Kristel;Goate, Alison M.;Fievet, Nathalie;Huentelman, Matthew J.;Gill, Michael;Brown, Kristelle;Kamboh, M. Ilyas;Keller, Lina;Barberger-Gateau, Pascale;McGuinness, Bernadette;Larson, Eric B.;Green, Robert;Myers, Amanda J.;Dufouil, Carole;Todd, Stephen;Wallon, David;Love, Seth;Rogaeva, Ekaterina;Gallacher, John;St George-Hyslop, Peter;Clarimon, Jordi;Lleo, Alberto;Bayer, Anthony;Tsuang, Debby W.;Yu, Lei;Tsolaki, Magda;Bossu, Paola;Spalletta, Gianfranco;Proitsi, Petroula;Collinge, John;Sorbi, Sandro;Sanchez-Garcia, Florentino;Fox, Nick C.;Hardy, John;Naranjo, Maria Candida Deniz;Bosco, Paolo;Clarke, Robert;Brayne, Carol;Galimberti, Daniela;Mancuso, Michelangelo;Matthews, Fiona;Moebus, Susanne;Mecocci, Patrizia;Del Zompo, Maria;Maier, Wolfgang;Hampel, Harald;Pilotto, Alberto;Bullido, Maria;Panza, Francesco;Caffarra, Paolo;Nacmias, Benedetta;Gilbert, John R.;Mayhaus, Manuel;Lannfelt, Lars;Hakonarson, Hakon;Pichler, Sabrina;Carrasquillo, Minerva M.;Ingelsson, Martin;Beekly, Duane;Alvarez, Victoria;Zou, Fanggeng;Valladares, Otto;Younkin, Steven G.;Coto, Eliecer;Hamilton-Nelson, Kara L.;Gu, Wei;Razquin, Cristina;Pastor, Pau;Mateo, Ignacio;Owen, Michael J.;Faber, Kelley M.;Jonsson, Palmi V.;Combarros, Onofre;O'Donovan, Michael C.;Cantwell, Laura B.;Soininen, Hilkka;Blacker, Deborah;Mead, Simon;Mosley, Thomas H., Jr.;Bennett, David A.;Harris, Tamara B.;Fratiglioni, Laura;Holmes, Clive;de Bruijn, Renee F. A. G.;Passmore, Peter;Montine, Thomas J.;Bettens, Karolien;Rotter, Jerome I.;Brice, Alexis;Morgan, Kevin;Foroud, Tatiana M.;Kukull, Walter A.;Hannequin, Didier;Powell, John F.;Nalls, Michael A.;Ritchie, Karen;Lunetta, Kathryn L.;Kauwe, John S. K.;Boerwinkle, Eric;Riemenschneider, Matthias;Boada, Merce;Hiltunen, Mikko;Martin, Eden R.;Schmidt, Reinhold;Rujescu, Dan;Wang, Li-San;Dartigues, Jean-Francois;Mayeux, Richard;Tzourio, Christophe;Hofman, Albert;Noethen, Markus M.;Graff, Caroline;Psaty, Bruce M.;Jones, Lesley;Haines, Jonathan L.;Holmans, Peter A.;Lathrop, Mark;Pericak-Vance, Margaret A.;Launer, Lenore J.;Farrer, Lindsay A.;van Duijn, Cornelia M.;Van Broeckhoven, Christine;Moskvina, Valentina;Seshadri, Sudha;Williams, Julie;Schellenberg, Gerard D.;Amouyel, Philippe
先前的研究确定了晚发性阿尔茨海默病（LOAD）的11个易感基因座;然而，这种疾病的大部分遗传风险仍然无法解释。我们对欧洲血统个体的全基因组关联研究（GWAS）进行了一项大型的两阶段荟萃分析。在第一阶段，我们使用基因分型和插补数据（7，055，881个SNP）对4个先前发表的GWAS数据集进行荟萃分析，这些数据集包括17，008例阿尔茨海默病病例和37，154例对照。在第2阶段，对11632个SNP进行了基因分型，并在8,572个阿尔茨海默病病例和11,312个对照的独立组中进行了相关性测试。除了APOE基因座（编码载脂蛋白E），在1期和2期联合分析中，19个基因座达到全基因组显著性（P < 5 × 10−8），其中11个是新发现的与阿尔茨海默病相关的基因座。
Eleven susceptibility loci for late-onset Alzheimer’s disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer’s disease cases and 37,154 controls. In stage 2,11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer’s disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer’s disease.
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DOI：
10.4049/jimmunol.1200887
发表时间：
2012-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bao M;Hanabuchi S;Facchinetti V;Du Q;Bover L;Plumas J;Chaperot L;Cao W;Qin J;Sun SC;Liu YJ
通讯作者：
Liu YJ
影响因子：
4
作者：
Lambert, Jean-Charles;Grenier-Boley, Benjamin;Amouyel, Philippe
通讯作者：
Amouyel, Philippe
DOI：
10.1056/nejmoa1211851
发表时间：
2013-01-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Guerreiro R;Wojtas A;Bras J;Carrasquillo M;Rogaeva E;Majounie E;Cruchaga C;Sassi C;Kauwe JS;Younkin S;Hazrati L;Collinge J;Pocock J;Lashley T;Williams J;Lambert JC;Amouyel P;Goate A;Rademakers R;Morgan K;Powell J;St George-Hyslop P;Singleton A;Hardy J;Alzheimer Genetic Analysis Group
通讯作者：
Alzheimer Genetic Analysis Group
影响因子：
30.8
作者：
Harold, Denise;Abraham, Richard;Hollingworth, Paul;Sims, Rebecca;Gerrish, Amy;Hamshere, Marian L.;Pahwa, Jaspreet Singh;Moskvina, Valentina;Dowzell, Kimberley;Williams, Amy;Jones, Nicola;Thomas, Charlene;Stretton, Alexandra;Morgan, Angharad R.;Lovestone, Simon;Powell, John;Proitsi, Petroula;Lupton, Michelle K.;Brayne, Carol;Rubinsztein, David C.;Gill, Michael;Lawlor, Brian;Lynch, Aoibhinn;Morgan, Kevin;Brown, Kristelle S.;Passmore, Peter A.;Craig, David;McGuinness, Bernadette;Todd, Stephen;Holmes, Clive;Mann, David;Smith, A. David;Love, Seth;Kehoe, Patrick G.;Hardy, John;Mead, Simon;Fox, Nick;Rossor, Martin;Collinge, John;Maier, Wolfgang;Jessen, Frank;Schuermann, Britta;van den Bussche, Hendrik;Heuser, Isabella;Kornhuber, Johannes;Wiltfang, Jens;Dichgans, Martin;Froelich, Lutz;Hampel, Harald;Huell, Michael;Rujescu, Dan;Goate, Alison M.;Kauwe, John S. K.;Cruchaga, Carlos;Nowotny, Petra;Morris, John C.;Mayo, Kevin;Sleegers, Kristel;Bettens, Karolien;Engelborghs, Sebastiaan;De Deyn, Peter P.;Van Broeckhoven, Christine;Livingston, Gill;Bass, Nicholas J.;Gurling, Hugh;McQuillin, Andrew;Gwilliam, Rhian;Deloukas, Panagiotis;Al-Chalabi, Ammar;Shaw, Christopher E.;Tsolaki, Magda;Singleton, Andrew B.;Guerreiro, Rita;Muehleisen, Thomas W.;Noethen, Markus M.;Moebus, Susanne;Joeckel, Karl-Heinz;Klopp, Norman;Wichmann, H-Erich;Carrasquillo, Minerva M.;Pankratz, V. Shane;Younkin, Steven G.;Holmans, Peter A.;O'Donovan, Michael;Owen, Michael J.;Williams, Julie
通讯作者：
Williams, Julie
影响因子：
11
作者：
Chapuis, J.;Hansmannel, F.;Gistelinck, M.;Mounier, A.;Van Cauwenberghe, C.;Kolen, K. V.;Geller, F.;Sottejeau, Y.;Harold, D.;Dourlen, P.;Grenier-Boley, B.;Kamatani, Y.;Delepine, B.;Demiautte, F.;Zelenika, D.;Zommer, N.;Hamdane, M.;Bellenguez, C.;Dartigues, J-F;Hauw, J-J;Letronne, F.;Ayral, A-M;Sleegers, K.;Schellens, A.;Broeck, L. V.;Engelborghs, S.;De Deyn, P. P.;Vandenberghe, R.;O'Donovan, M.;Owen, M.;Epelbaum, J.;Mercken, M.;Karran, E.;Bantscheff, M.;Drewes, G.;Joberty, G.;Campion, D.;Octave, J-N;Berr, C.;Lathrop, M.;Callaerts, P.;Mann, D.;Williams, J.;Buee, L.;Dewachter, I.;Van Broeckhoven, C.;Amouyel, P.;Moechars, D.;Dermaut, B.;Lambert, J-C
通讯作者：
Lambert, J-C