Protein-protein interactions in the assembly and subcellular trafficking of the BACE (β-site amyloid precursor protein-cleaving enzyme) complex of Alzheimer's disease
Protein-protein interactions in the assembly and subcellular trafficking of the BACE (β-site amyloid precursor protein-cleaving enzyme) complex of Alzheimer's disease
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DOI：
10.1042/bst0350974
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发表时间：
2007-11-01
影响因子：
3.9
通讯作者：
Austen, B. M.
中科院分区：
文献类型：
--
作者：
Parsons, R. B.;Austen, B. M.
BACE （β -位点淀粉样前体蛋白切割酶或β -分泌酶）复合物的正确组装及其随后与APP（淀粉样前体蛋白）结合到细胞区室的运输对于A β（淀粉样β -肽）的产生至关重要，该蛋白聚集成老年斑被认为是AD（阿尔茨海默病）发病的原因。这些过程依赖于瞬时和永久的bace -蛋白相互作用。这篇综述将讨论目前已知的bace -蛋白相互作用，以及它们如何揭示治疗AD的新靶点。
The correct assembly of the BACE (beta-site amyloid precursor protein-cleaving enzyme or beta-secretase) complex and its subsequent trafficking to cellular compartments where it associates with the APP (amyloid precursor protein) is essential for the production of A beta (amyloid beta-pepticle), the protein whose aggregation into senile plaques is thought to be responsible for the pathogenesis of AD (Alzheimer's disease). These processes rely upon both transient and permanent BACE-protein interactions. This review will discuss what is currently known about these BACE-protein interactions and how they may reveal novel therapeutic targets for the treatment of AD.