THE EFFECT OF TRICLOFOS SODIUM SEDATION ON RESPIRATORY RATE, OXYGEN-SATURATION, AND HEART-RATE IN INFANTS AND YOUNG-CHILDREN
THE EFFECT OF TRICLOFOS SODIUM SEDATION ON RESPIRATORY RATE, OXYGEN-SATURATION, AND HEART-RATE IN INFANTS AND YOUNG-CHILDREN
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DOI：
10.1002/ppul.1950100109
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发表时间：
1991-01-01
影响因子：
3.1
通讯作者：
STOCKS, J
中科院分区：
文献类型：
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作者：
JACKSON, EA;RABBETTE, PS;STOCKS, J
水合氯醛经常用于镇静婴儿以进行肺功能测试。 虽然尚未证明对呼吸功能有影响，但最近的一项研究报告称，喘息婴儿镇静后血氧饱和度 (Sa(o2)) 下降。 本研究旨在评估密切相关但胃刺激性较小的药物三氯磷钠对无心肺疾病婴儿呼吸频率 (RR)、心率 (HR) 和 Sa(o2) 的影响。 使用呼吸感应体积描记法和脉搏血氧饱和度法对 10 名婴儿（4-19 个月大）在自然睡眠和镇静睡眠期间进行配对测量。 使用三氯磷镇静后，平均 RR 上升 1.9 次呼吸 min-1（平均差异的 95% 置信区间 [CI]：0.13-3.7 min-1）。 平均心率上升 5.5 次 min-1（95% CI：-0.9-11.9 min-1）。 平均 Sa(o2) 下降 0.68% (95% CI - 1.8-0.45%)。 这些变化均不被认为具有临床重要性，只有 RR 的变化达到 5% 水平的统计显着性。
Chloral hydrate is frequently used to sedate infants for lung function testing. While no effect on respiratory function has been demonstrated, a recent study has reported a fall in oxygen saturation (Sa(o2)) following sedation in wheezy infants. This study was designed to assess the effects of the closely related but less gastrically irritant drug triclofos sodium on respiratory rate (RR), heart rate (HR), and Sa(o2) in infants without cardiopulmonary disease. Paired measurements using respiratory inductance plethysmography and pulse oximetry were obtained in 10 infants (4-19 months of age) during natural and sedated sleep. Following sedation with triclofos, mean RR rose by 1.9 breaths min-1 (95% confidence intervals [CI] of the mean difference: 0.13-3.7 min-1). Mean heart rate rose by 5.5 beats min-1 (95% CI: -0.9-11.9 min-1). Mean Sa(o2) fell by 0.68% (95% CI - 1.8-0.45%). None of these changes are considered to be of clinical importance, and only the change in RR reached statistical significance at the 5% level.