Effect of stretch combined with electrical stimulation on the type of sarcomeres produced at the ends of muscle fibers.
Effect of stretch combined with electrical stimulation on the type of sarcomeres produced at the ends of muscle fibers.
复制标题
拉伸结合电刺激对肌纤维末端产生的肌节类型的影响。
DOI：
10.1016/0014-4886(86)90170-6
复制
发表时间：
1986
影响因子：
5.3
通讯作者：
Goldspink,G
中科院分区：
文献类型：
--
作者：
Williams,P;Watt,P;Bicik,V;Goldspink,G
拉伸肌肉导致肌肉纤维末端的肌节快速增加。研究了一种类似于慢速运动神经元的电刺激模式对拉伸快速收缩肌肉中新形成的肌肉组织的影响。我们发现，在短短4天的时间后，添加到现有肌原纤维末端的肌节类型与实验肌肉中间区域的肌节类型不同：在拉伸刺激的末端，I型和IIA型肌节的比例要高得多。这项研究表明，通过使用电刺激结合拉伸，可以在很短的时间内实现和检测纤维类型特异性收缩蛋白合成的重编程。
Stretching a muscle results in a rapid addition of sarcomeres at the ends of the muscle fibers. The effect of a pattern of electrical stimulation resembling that of a slow motoneuron on the newly formed muscle tissue in a stretched, fast-contracting muscle was investigated. We found that after a period as short as 4 days, the type of sarcomeres which were added on to the ends of the existing myofibrils differed from those in the middle regions of the experimental muscles: there was a much higher proportion of type I and type IIA sarcomeres in the stretch-stimulated ends. This study showed that reprogramming of the synthesis of fiber type-specific contractile proteins can be achieved and detected within a very short time by using electrical stimulation combined with stretch.