Adaptive differentiation of murine lymphocytes. I. Both T and B lymphocytes differentiating in F1 transplanted to parental chimeras manifest preferential cooperative activity for partner lymphocytes derived from the same parental type corresponding to the chimeric host
Adaptive differentiation of murine lymphocytes. I. Both T and B lymphocytes differentiating in F1 transplanted to parental chimeras manifest preferential cooperative activity for partner lymphocytes derived from the same parental type corresponding to the chimeric host
复制标题
小鼠淋巴细胞的适应性分化。
DOI：
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发表时间：
1978
影响因子：
15.3
通讯作者：
C. Bogowitz
中科院分区：
文献类型：
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作者：
D. H. Katz;B. Skidmore;L. R. Katz;C. Bogowitz
适应性（选择性）分化的概念意味着淋巴细胞的早期分化是由分化发生的环境所决定的。这些过程似乎涉及淋巴细胞的选择，根据他们之间的相互作用的淋巴细胞的自我识别是，至少部分地，由主要组织相容性复合物连锁基因控制，然后适应性分化也由这些基因控制。在这些研究中，我们已经测试了在两个亲本菌株之间制备的骨髓嵌合体的各种组合的环境中引发的辅助T淋巴细胞和半抗原特异性B淋巴细胞的能力（即A/J和BALB/c）及其相应的F1杂种（CAF 1）与来自常规亲本和F1供体的致敏B和T淋巴细胞以及所有相应的骨髓嵌合体相互作用组合。结果清楚地表明，（a）移植到F1嵌合淋巴细胞中的F1在与所有各种配偶体细胞组合的协同活性方面没有表现出限制;（B）移植到F1嵌合淋巴细胞的亲本仅对来自F）或对应于原始骨髓供体单倍型的亲本供体的配偶体细胞表现出有效的协同活性，从而表现出与常规亲本淋巴细胞一样的表型;和（c）移植到亲本嵌合淋巴细胞的F1在与完全或共显性地共享亲本嵌合宿主的H-2单倍型的配偶淋巴细胞最佳合作方面显示出受限的单倍型偏好。这些研究结果的影响，了解某些控制淋巴细胞分化的机制进行了讨论。
The concept of adaptive (selective) differentiation preducts that early differentiation of lymphocytes is conditioned by the environment in which such differentiation takes place. These processes appear to involve selection of lymphocytes according to their self-recognition between interacting lymphocytes is, at least in part, controlled by major histocompatibility complex-linked genes, then adaptive differentiation is also controlled by these genes. In these studies, we have tested the capacities of helper T lymphocytes and hapten-specific B lymphocytes primed in the environments of various combinations of bone marrow chimeras prepared between two parental strains (i.e. A/J and BALB/c) and their corresponding F1 hybrid (CAF1) to interact with primed B and T lymphocytes derived from conventional parent and F1 donors as well as all of the corresponding bone marrow chimera combinations. The results demonstrate clearly that (a) F1 transplanted to F1 chimeric lymphocytes display no restriction in terms of cooperative activity with all of the various partner cell combinations; (b) parent transplanted to F1 chimeric lymphocytes manifest effective cooperative activity only for partner cells from F) or parental donors corresponding to the haplotype of the original bone marrow donor, thereby behaving phenotypically just like conventional parental lymphocytes; and (c) F1 transplanted to parent chimeric lymphocytes display restricted haplotype preference in cooperating best with partner lymphocytes sharing the H-2 haplotype, either entirely or codomimantly, of the parental chimeric host. The implications of these findings for understanding certain controlling mechanisms for lymphocyte differentiation are discussed.