Metabolism and the Control of Cell Fate Decisions and Stem Cell Renewal.
Metabolism and the Control of Cell Fate Decisions and Stem Cell Renewal.
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DOI：
10.1146/annurev-cellbio-111315-125134
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发表时间：
2016-10-06
影响因子：
11.3
通讯作者：
Ito K
中科院分区：
文献类型：
--
作者：
Ito K;Ito K
尽管各种组织的干细胞保持静止状态以维持其未分化状态，但它们也会根据需要进行细胞分裂，如果需要，即使是单个干细胞也能够提供终生的组织稳态。干细胞群受到其对称和不对称分裂之间的平衡的精确控制，其分裂模式取决于所涉及的子细胞是否保留其自我更新能力。最近的研究报道，代谢途径和线粒体的分布是干细胞分裂平衡的调节者，代谢缺陷可以将分裂平衡转向对称承诺，从而导致干细胞衰竭。还观察到，在不对称分裂中，作为中央代谢细胞器的老线粒体被分离到注定细胞分化的子细胞，而在对称分裂中，年轻和老线粒体在两个子细胞之间平均分配。因此，新陈代谢和线粒体生物学在干细胞命运决定中发挥着重要作用。由于这些决定直接影响组织稳态，因此了解它们在细胞代谢背景下的调节机制至关重要。
Although the stem cells of various tissues remain in the quiescent state to maintain their undifferentiated state, they also undergo cell divisions as required, and if necessary, even a single stem cell is able to provide for lifelong tissue homeostasis. Stem cell populations are precisely controlled by the balance between their symmetric and asymmetric divisions, with their division patterns determined by whether the daughter cells involved retain their self-renewal capacities. Recent studies have reported that metabolic pathways and the distribution of mitochondria are regulators of the division balance of stem cells and that metabolic defects can shift division balance toward symmetric commitment, which leads to stem cell exhaustion. It has also been observed that in asymmetric division, old mitochondria, which are central metabolic organelles, are segregated to the daughter cell fated to cell differentiation, whereas in symmetric division, young and old mitochondria are equally distributed between both daughter cells. Thus, metabolism and mitochondrial biology play important roles in stem cell fate decisions. As these decisions directly affect tissue homeostasis, understanding their regulatory mechanisms in the context of cellular metabolism is critical.
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DOI：
10.1038/nrm3772
发表时间：
2014-04
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1039/c3ib40163d
发表时间：
2014-03
期刊：
Integrative biology : quantitative biosciences from nano to macro
影响因子：
--
作者：
Carulli AJ;Samuelson LC;Schnell S
通讯作者：
Schnell S
影响因子：
64.5
作者：
Kiel, MJ;Yilmaz, ÖH;Morrison, SJ
通讯作者：
Morrison, SJ
影响因子：
64.8
作者：
Busch, Katrin;Klapproth, Kay;Rodewald, Hans-Reimer
通讯作者：
Rodewald, Hans-Reimer
影响因子：
23.9
作者：
Dykstra, Brad;Kent, David;Eaves, Connie
通讯作者：
Eaves, Connie