Children of the Twins Early Development Study (CoTEDS): A Children-of-Twins Study.
Children of the Twins Early Development Study (CoTEDS): A Children-of-Twins Study.
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双胞胎儿童早期发育研究 (CoTEDS)：一项双胞胎儿童研究。
DOI：
10.1017/thg.2019.61
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
McAdams,TomA
中科院分区：
文献类型：
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作者：
Ahmadzadeh,YasminI;Eley,ThaliaC;Plomin,Robert;Dale,PhilipS;Lester,KathrynJ;Oliver,BonamyR;McMillan,Andrew;McAdams,TomA
双胞胎儿童早期发展研究（CoTEDS）是英国一项新的前瞻性双胞胎儿童研究，旨在调查儿童发育阶段的代际关联。CoTEDS将使人们能够研究支持亲子关系的遗传和环境因素，重点是心理健康和认知相关特征。通过CoTEDS，我们将有一个新的透镜来研究父母在影响儿童发展方面所扮演的角色，以及塑造养育行为和经验的遗传和环境因素。目前正在从大约20，000名可接触的成年双胞胎中进行招募，这些双胞胎自婴儿期起就参加了双胞胎早期发育研究（TEDS）。TEDS双胞胎被邀请在出生时将所有后代登记到CoTEDS，截至2019年5月，共有554名儿童登记。通过招募第二代TEDS参与者，CoTEDS将包括成年双胞胎及其婴儿期后代的信息。目前正在对1岁和2岁的CoTEDS婴儿进行基于父母问卷的数据收集，并计划进行进一步的数据收集。目前的数据收集包括以下主要结构：儿童心理健康，气质，语言和认知发展;父母心理健康和社会关系;养育行为和感情;和其他社会生态因素。参照现有的遗传信息队列研究选择了测量工具，以确保在相应的发育阶段测量的表型重叠。这种内置的研究重叠旨在使未来的分析在样本和研究设计中能够重复和三角测量。在这里，我们总结了研究方案和测量程序，并描述了未来的计划。
The Children of the Twins Early Development Study (CoTEDS) is a new prospective children-of-twins study in the UK, designed to investigate intergenerational associations across child developmental stages. CoTEDS will enable research on genetic and environmental factors that underpin parent–child associations, with a focus on mental health and cognitive-related traits. Through CoTEDS, we will have a new lens to examine the roles that parents play in influencing child development, as well as the genetic and environmental factors that shape parenting behavior and experiences. Recruitment is ongoing from the sample of approximately 20,000 contactable adult twins who have been enrolled in the Twins Early Development Study (TEDS) since infancy. TEDS twins are invited to register all offspring to CoTEDS at birth, with 554 children registered as of May 2019. By recruiting the second generation of TEDS participants, CoTEDS will include information on adult twins and their offspring from infancy. Parent questionnaire-based data collection is now underway for 1- and 2-year-old CoTEDS infants, with further waves of data collection planned. Current data collection includes the following primary constructs: child mental health, temperament, language and cognitive development; parent mental health and social relationships; parenting behaviors and feelings; and other socioecological factors. Measurement tools have been selected with reference to existing genetically informative cohort studies to ensure overlap in phenotypes measured at corresponding stages of development. This built-in study overlap is intended to enable replication and triangulation of future analyses across samples and research designs. Here, we summarize study protocols and measurement procedures and describe future plans.