Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: is it appropriate?
Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: is it appropriate?
复制标题
使用当归（Angelica sinensis）治疗乳腺癌女性的围绝经期或绝经后症状：是否合适？
作者：
C. Lau;Tony C Y Ho;Terry W L Chan;Stephen Kim
目的：关于越来越多地使用替代疗法治疗绝经期或绝经后症状，我们评估了当归（当归）的水提取物，用于缓解绝经期或绝经后症状，对雌激素受体阳性（MCF-7）和阴性（BT-20）乳腺癌细胞增殖的影响。设计：采用MTT法检测当归水提取物单独或与17β-雌二醇和4-羟基三苯氧胺共同作用对MCF-7和BT-20细胞生长的影响。结果：当归水提物对17β-雌二醇诱导的MCF-7细胞增殖有明显的剂量依赖性，但对4-羟基三苯氧胺有明显的抑制作用。同时，无论是否加入17β-雌二醇，该提取物均对BT-20具有明显的促生长作用，且呈剂量依赖性。在17β-雌二醇或4-羟基三苯氧胺存在下，用提取物处理BT-20细胞的生长没有发现明显差异。结论：当归水提物对乳腺癌MCF-7细胞的增殖有促进作用，可能依赖于弱的雌激素激动活性，而对BT-20细胞的增殖有促进作用，不依赖于雌激素受体介导的途径。本研究提供了有关雌激素样活性的当归，这可能有助于决策的妇女在使用草药治疗雌激素敏感和不敏感的乳腺癌的风险。由于缺乏临床数据证明当归的潜在副作用，其用于治疗绝经后或绝经后症状的草药制剂，特别是乳腺癌妇女，值得谨慎，有待进一步研究。
Objective:Regarding the growing use of alternative therapies for peri- or postmenopausal symptoms, we evaluated the effect of a water extract of Angelica sinensis (dong quai), used for peri- or postmenopausal relief, on the proliferation of estrogen receptor-positive (MCF-7) and negative (BT-20) breast cancer cells in vitro. Design:The present study was designed to investigate the growth-modulating effect of dong quai water extract, alone or in the presence of 17β-estradiol and 4-hydroxytamoxifen, on MCF-7 and BT-20 cell cultures using MTT proliferation assay. Results:The water extract of dong quai dose-dependently and significantly stimulated the proliferation of MCF-7 cells with a weak estrogen-agonistic activity in the presence of 17β-estradiol, as evidenced by the significant suppression by 4-hydroxytamoxifen. Meanwhile, the extract significantly exerted a growth-stimulating effect on BT-20 in a dose-dependent manner with or without 17β-estradiol. No obvious difference was found in the growth of BT-20 cells treated with the extract in the presence of 17β-estradiol or 4-hydroxytamoxifen. Conclusions:The water extract of dong quai stimulated the growth of MCF-7 cells, possibly dependent of weak estrogen-agonistic activity, and augmented the BT-20 cell proliferation independent of estrogen receptor-mediated pathway. The present study provides data regarding the estrogen-like activity of dong quai, which might assist in decision making on herbal therapy use by women at risk for both estrogen-sensitive and insensitive breast cancer. Because of the lack of clinical data demonstrating the potential side effects of dong quai, its use in herbal preparations for the treatment of peri- or postmenopausal symptoms, especially in women with breast cancer, warrants caution pending further study.
雌二醇代谢：调节人类乳腺癌发生的内分泌生物标志物。
影响因子：
10.4
作者：
Telang,NT;Katdare,M;Bradlow,HL;Osborne,MP
通讯作者：
Osborne,MP