CLATHRIDINE AND ITS ZINC COMPLEX, NOVEL METABOLITES FROM THE MARINE SPONGE CLATHRINA-CLATHRUS
CLATHRIDINE AND ITS ZINC COMPLEX, NOVEL METABOLITES FROM THE MARINE SPONGE CLATHRINA-CLATHRUS
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DOI：
10.1016/s0040-4020(01)89246-2
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发表时间：
1989-01-01
期刊：
影响因子：
2.1
通讯作者：
MANGONI, A
中科院分区：
文献类型：
--
作者：
CIMINIELLO, P;FATTORUSSO, E;MANGONI, A
一种含咪唑的化合物，即克拉啶（1）的结构是根据化学证据和广泛的核磁共振分析确定的。从海绵Clathrina clathrus中分离得到的Clathridine具有抗真菌活性。该海绵还含有少量的克拉屈啶（4）的锌络合物，其已根据其光谱性质鉴定并由1与硫酸锌合成。并对4的立体结构提出了假设。
The structure of an imidazole-containing compound, clathridine (1), was established from chemical evidence and by extensive NMR analysis. Clathridine was isolated from the sponge Clathrina clathrus and exhibited antimycotic activity. The sponge also contains smaller quantities of a Zn-complex of clathridine (4), which has been identified on the basis of its specroscopic properties and synthesized from 1 with ZnSO4. A hypothesis for the stereostructure of 4 is also given.