Serum amyloid A -: an indicator of inflammation in ankylosing spondylitis
Serum amyloid A -: an indicator of inflammation in ankylosing spondylitis
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DOI：
10.1007/s002960050114
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发表时间：
2000-04-01
影响因子：
4
通讯作者：
Neeck, G
中科院分区：
文献类型：
--
作者：
Lange, U;Boss, B;Neeck, G
炎症生物学标志物可用于炎症性风湿病的诊断和监测。本研究旨在探讨血清淀粉样蛋白A（SAA）是否可作为强直性脊柱炎（AS）炎症活动的标志物。在72例AS患者中，红细胞沉降率（ESR）和C-反应蛋白（CRP）这两个有价值的疾病活动性替代标志物以及已建立的临床活动性评分（Bath强直性脊柱炎疾病活动指数，BASDAI）与血清SAA水平相关。SAA与ESR、CRP、BASDAI相关性良好。由于其强相关性，SAA似乎是一个额外的非常有用的疾病活动标记。当用于诊断，特别是监测炎症时，需要进一步的研究。另一个有趣的观点是血浆SAA作为淀粉样蛋白A（AA）蛋白前体在继发性淀粉样变性（AS的一种已知并发症）中的作用。在所有的可能性，高循环SAA水平是疾病活动的易感指标。
Biological markers of inflammation are useful for the diagnosis and monitoring of inflammatory rheumatic diseases. The present study tested, whether serum amyloid A (SAA) could be used as a marker of inflammatory disease activity in ankylosing spondylitis (AS). In 72 patients with AS, the two valuable surrogate markers of disease activity, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), and an established clinical activity score (Bath Ankylosing Spondylitis Disease Activity Index, BASDAI) were correlated to the serum levels of SAA. It was found that SAA correlates well with ESR, CRP, and BASDAI. Because of its strong correlation, SAA seems to be an additional very useful disease activity marker. When used in diagnosis, and especially in monitoring of inflammation, further studies are required. Another interesting point of view is the described role of plasma SAA as a precursor of Amyloid A (AA) protein in secondary amyloidosis, a known complication in AS. In all probability, high circulating SAA levels are a predisposing indicator of disease activity.