Brefeldin A revealing the fundamental principles governing membrane dynamics and protein transport.
Brefeldin A revealing the fundamental principles governing membrane dynamics and protein transport.
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Brefeldin A 揭示了控制膜动力学和蛋白质运输的基本原理。
DOI：
10.1007/0-306-46824-7_6
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发表时间：
2000
影响因子：
--
通讯作者：
Jackson,CL
中科院分区：
文献类型：
--
作者：
Jackson,CL
Brefeldin A(BFA)在真核细胞中被广泛用作蛋白质分泌的抑制因子。BFA于1958年首次被描述(Singleton et al.，1958)，是一种由某些真菌产生的杂环内酯。在20世纪80年代中期，S被证明对真核细胞内细胞器的结构和功能有显著影响，特别是高尔基体(DOMS等人，1989；Hunziker等人，1992；Lippincott-Schwartz等人，1991；Lippincott-Schwartz等人，1989；Misumi等人，1986)。这一发现使人们对该药物产生了浓厚的兴趣，这既是为了了解细胞内间隔组织的潜在机制，也是为了作为一种工具来特异性地抑制分泌途径的功能
Brefeldin A (BFA) has enjoyed widespread use as an inhibitor of protein secretion in eukaryotic cells. BFA, first described in 1958 (Singleton et al., 1958), is a heterocyclic lactone produced by certain fungi. In the mid-1980’s, BFA was demonstrated to have dramatic effects on the structure and functioning of intracellular organelles, particularly the Golgi apparatus, in eukaryotic cells (Doms et al., 1989; Hunziker et al., 1992; Lippincott-Schwartz et al., 1991; Lippincott-Schwartz et al., 1989; Misumi et al., 1986). This discovery led to intense interest in the drug both for understanding the mechanisms underlying the organization of intracellular compartments and as a tool to specifically inhibit the functioning of the secretory pathway