MORPHOMETRIC ANALYSIS OF MACULAR PHOTORECEPTORS AND GANGLION-CELLS IN RETINAS WITH RETINITIS-PIGMENTOSA
MORPHOMETRIC ANALYSIS OF MACULAR PHOTORECEPTORS AND GANGLION-CELLS IN RETINAS WITH RETINITIS-PIGMENTOSA
复制标题
DOI：
10.1001/archopht.1992.01080230134038
复制
发表时间：
1992-11-01
影响因子：
--
通讯作者：
MILAM, AH
中科院分区：
文献类型：
--
作者：
STONE, JL;BARLOW, WE;MILAM, AH
已有一些视网膜组织病理学研究是从视网膜色素变性(RP)患者的身体上取得的，但很少涉及继发于感光细胞死亡的神经节细胞跨神经元变性的问题。我们研究了41例不同遗传类型的RP患者的黄斑切片：常染色体显性遗传型(n=11)、X连锁遗传型(n=9)和单纯型(n=21)。我们还研究了20名年龄匹配的正常人的黄斑切片。我们从黄斑中心凹到偏心1500微米，每隔100微米(0.35度)计数光感受器层和神经节细胞层的细胞体，并用反相计数法比较各组之间的平均细胞计数。每种类型的RP值均显著低于对照组(P
There have been a number of histopathologic studies of retinas that were taken post mortem from patients with retinitis pigmentosa (RP), but few have addressed the question of transneuronal degeneration of ganglion cells secondary to photoreceptor death. We studied sectioned maculae that were obtained from 41 patients with different genetic forms of RP: autosomal dominant (n=11); X-linked (n=9); and simplex (n=21). We also studied sectioned maculae that were taken from 20 age-matched normal subjects. We counted cell bodies in the photoreceptor and ganglion cell layers at 1 00-mum (0.35-degrees) intervals from the foveola to 1500-mum eccentricity and compared the mean cell counts among each group with RP. Each RP type had significantly fewer (P