Clinical pregnancies and livebirths achieved by intracytoplasmic injection of round headed acrosomeless spermatozoa with and without oocyte activation in familial globozoospermia: case report
Clinical pregnancies and livebirths achieved by intracytoplasmic injection of round headed acrosomeless spermatozoa with and without oocyte activation in familial globozoospermia: case report
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DOI：
10.1111/j.1745-7262.2008.00248.x
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发表时间：
2008-03-01
影响因子：
2.9
通讯作者：
Suludere, Zekiye
中科院分区：
文献类型：
--
作者：
Dirican, Enver K.;Isik, Ahmet;Suludere, Zekiye
我们报告了两个患有家族性球精子症的兄弟姐妹行卵胞浆内单精子注射(ICSI)治疗的成功结果。经控制性超排卵和取卵后，1例获卵行ICSI前机械激活，受精率为33.3%。第二对夫妇在不激活卵母细胞的情况下进行了ICSI，受精率为9.1%。第一对夫妇移植了两个I级胚胎，第二对夫妇移植了一个I级胚胎，导致了临床妊娠和健康的活产。结论：球状精子症患者的主要问题是受精率低，即使ICSI和卵母细胞激活可以提高受精率，但不一定需要获得妊娠。
We report the successful outcome of intracytoplasmic sperm injection ( ICSI) treatment in two siblings with familial globozoospermia. After controlled ovarian hyperstimulation and oocyte pick-up, retrieved oocytes were mechanically activated before ICSI and a fertilization rate of 33.3% was achieved in the first case. The second couple underwent ICSI without oocyte activation and a 9.1% fertilization rate was obtained. The transfer of two grade I embryos in the first couple and one grade I embryo in the second couple resulted in clinical pregnancies with healthy livebirths. It was concluded that the main problem of cases with globozoospermia is a low fertilization rate, and even though ICSI and oocyte activation can increase this rate it is not necessarily needed to achieve a pregnancy.