Focal Lamina Cribrosa Defect in Myopic Eyes With Nonprogressive Glaucomatous Visual Field Defect
Focal Lamina Cribrosa Defect in Myopic Eyes With Nonprogressive Glaucomatous Visual Field Defect
复制标题
伴有非进行性青光眼视野缺损的近视眼局灶性筛板缺损
DOI：
10.1016/j.ajo.2018.03.018
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发表时间：
2018
影响因子：
4.2
通讯作者：
Yoshitomi Takeshi
中科院分区：
文献类型：
--
作者：
Sawada Yu;Araie Makoto;Kasuga Hitomi;Ishikawa Makoto;Iwata Toyoto;Murata Katsuyuki;Yoshitomi Takeshi
目的探讨近视眼非进行性青光眼视野缺陷(VFD)在空间上对应的局灶性筛板(LC)缺陷。设计病例对照研究对象：159只近视眼治疗中的青光眼VFD，随访7年。非进展性VFD定义为具有Humphrey视野的≤-1进行点，斜率用逐点线性回归方法计算，差于−1.0dB/年。结果64例(40.3%)患者表现为非进展性VFD，平均偏差−为0.06±0.22分贝/年。多因素Logistic回归分析显示，存在LC缺陷与非进展性VFD显著相关(优势比，3.96；P=0.002)。LC缺陷的位置在空间上对应于VFD的位置。非进展性LC缺陷者的基线眼压(16.6 mm Hgvs21.0 mm Hg，P=0.0030)和眼压变化百分比(12.9%vs30.5%，P<；0.0001)均低于无LC缺陷者，但近视视盘变形较大(扭转角度10.1°vs1.2°，P<；0.0001)。结论近视眼存在与非进行性青光眼VFD相关的特殊类型的Lc缺陷。
PurposeTo investigate focal lamina cribrosa (LC) defect that spatially correspond to the nonprogressive glaucomatous visual field defect (VFD) in myopic subjects.DesignCase-control study.SubjectsWe included 159 myopic eyes with glaucomatous VFD under treatment and followed up for 7 years.MethodsSerial enhanced-depth imaging spectral-domain optical coherence tomography B-scans of the optic discs were acquired at the end of the follow-up and reviewed for the LC defect. Nonprogressive VFD was defined as having ≤1 progressing point of Humphrey visual field, with a slope calculated using pointwise linear regression worse than −1.0 dB/year atP< .01. Eyes were classified as having either progressive or nonprogressive VFD, and associating factors were evaluated.ResultsSixty-four subjects (40.3%) exhibited nonprogressive VFD with mean deviation change −0.06 ± 0.22 dB/year. Multivariate logistic regression analysis revealed that presence of LC defect was significantly associated with nonprogressive VFD (odds ratio, 3.96;P= .002). The location of LC defect corresponded spatially to the location of VFD. Nonprogressive eyes with LC defect exhibited lower baseline intraocular pressure (IOP) (16.6 mm Hg vs 21.0 mm Hg,P= .0030) and smaller percentage of IOP change (12.9% vs 30.5%,P< .0001) than those without LC defect, but greater myopic optic disc deformation (10.1 degrees vs 1.2 degrees in torsion angle,P< .0001). When the eyes with LC defect had higher baseline IOP, they exhibited progressive VFD.ConclusionsIn myopic eyes, there are specific patters of LC defect that are suggested to be associated with nonprogressive glaucomatous VFD.