THE EFFECTS OF TOPICAL CAPSAICIN ON RAT URINARY-BLADDER MOTILITY INVIVO
THE EFFECTS OF TOPICAL CAPSAICIN ON RAT URINARY-BLADDER MOTILITY INVIVO
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DOI：
10.1016/0014-2999(84)90187-0
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发表时间：
1984-01-01
影响因子：
5
通讯作者：
MELI, A
中科院分区：
文献类型：
--
作者：
MAGGI, CA;SANTICIOLI, P;MELI, A
研究了氨基甲酸乙酯麻醉大鼠膀胱壁肿胀后外用辣椒素对膀胱运动的影响，并与外用P物质和乙酰胆碱的作用进行了比较。辣椒素和P物质在静止和有节奏收缩的膀胱中产生相似的兴奋作用，即TTX[河豚毒素]抗性强张性收缩，随后是一系列有节奏的，TTX敏感的，阶段性收缩。乙酰胆碱在产生TTX抗性收缩方面的剂量相同，但在触发膀胱肌肉神经源性节律性收缩方面的效果不如辣椒素或P物质。阿托品预处理阻止了辣椒素和P物质排泄作用的神经源性成分。重复使用辣椒素而不是P物质导致脱敏。用大剂量辣椒素预处理（4天前）的动物膀胱对局部辣椒素不敏感，需要更大体积的生理盐水来触发逼尿肌的神经源性节律性收缩。辣椒素显然是通过干扰排尿反射阈值的调节机制而起作用的。
The effects of topical capsaicin on urinary bladder motility were investigated following saline-induced distension of the bladder wall in urethane-anesthetized rats and compared to the effects of topical substance P and acetylcholine. Capsaicin and substance P produced similar excitatory effects in both quiescent and rhythmically contracting bladders, i.e., a TTX [tetrodotoxin] resistant tonic contraction followed by a series of rhythmic, TTX sensitive, phasic contractions. Acetylcholine, in doses equieffective in producing TTX resistant contractions, was less effective than capsaicin or substance P in triggering neurogenic rhythmic contractions of bladder muscle. Atropine pretreatment prevented the neurogenic component of the exictatory effect of both capsaicin and substance P. Repeated applications of capsaicin but not of substance P led to desensitization. Bladders of animals pretreated (4 days before) with a large dose of s.c. capsaicin developed insensitivity to topical capsaicin and a larger volume of saline was required to trigger neurogenic rhythmic contractions of the detrusor muscle. Capsaicin apparnetly acts by interfering with the mechanisms(s) regulating the threshold for the micturition reflex to occur.