Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function
Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function
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DOI：
10.1073/pnas.0805806106
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发表时间：
2009-05-05
影响因子：
11.1
通讯作者：
FitzGerald, Garret A.
中科院分区：
文献类型：
--
作者：
Wang, Dairong;Patel, Vickas V.;FitzGerald, Garret A.
Nonsteroidal anti-inflammatory drugs selective for inhibition of COX-2 increase heart failure and elevate blood pressure. The COX-2 gene was floxed and crossed into merCremer mice under the alpha-myosin heavy-chain promoter. Tamoxifen induced selective deletion of COX-2 in cardiomyocytes depressed cardiac output, and resulted in weight loss, diminished exercise tolerance, and enhanced susceptibility to induced arrhythmogenesis. The cardiac dysfunction subsequent to pressure overload recovered progressively in the knockouts coincident with increasing cardiomyocyte hypertrophy and interstitial and perivascular fibrosis. Inhibition of COX-2 in cardiomyocytes may contribute to heart failure in patients receiving nonsteroidal anti-inflammatory drugs specific for inhibition of COX-2.
