HORMONAL-REGULATION OF HEPATIC MICROSOMAL 11-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY IN RAT
HORMONAL-REGULATION OF HEPATIC MICROSOMAL 11-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY IN RAT
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DOI：
10.1530/acta.0.0890352
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发表时间：
1978-01-01
期刊：
影响因子：
--
通讯作者：
SCHRIEFERS, H
中科院分区：
文献类型：
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作者：
LAX, ER;GHRAF, R;SCHRIEFERS, H
肝微粒体11 β-雄性大鼠肝脏中的羟类固醇脱氢酶活性高于雌性大鼠肝脏。在出生后第25天进行性腺切除术仅影响成年雄性动物的活动，导致活动降低至正常雌性水平。雄性和雌性去势大鼠给药睾酮可诱导典型的雄性活动水平。这种酶的活性可以归类为雄激素依赖性。11. β-羟基类固醇脱氢酶与其他已知的雄激素依赖性活性的不同之处在于，对任一性别的性腺切除动物给予雌二醇会导致活性进一步显著抑制至接近检测限的水平。在出生后第50天切除垂体不会影响75日龄雄性大鼠的活动，但会导致雌性大鼠出现典型的雄性活动水平。垂体对肝11 β-受体发挥抑制作用。雌性大鼠的羟类固醇脱氢酶。一旦切除垂体，这种活性不受雄激素或雌激素的影响，这一事实表明垂体对性激素的作用是必不可少的。
Hepatic microsomal 11.beta.-hydroxysteroid dehydrogenase activity is higher in male than in female rat liver. Gonadectomy on day 25 of life only affects the activity in the adult male animal, causing a decrease towards the normal female level. Administration of testosterone to gonadectomized rats of either sex causes the induction of typical male activity levels. This enzyme activity may be classified as androgen-dependent. 11.beta.-Hydroxysteroid dehydrogenase differs from other known androgen-dependent activities in that administration of estradiol to gonadectomized animals of either sex causes a further significant repression of the activity to levels close to the limits of detection. Hypophysectomy on day 50 of life does not affect the activity in 75 day old male rats, but causes the appearance of typically male activity levels in females. The hypophysis exerts a repressive influence on hepatic 11.beta.-hydroxysteroid dehydrogenase in female rats. The fact that this activity is not influenced by androgen or estrogen administration once the pituitary has been removed demonstrates the obligatory role of the hypophysis for sex hormone action.