Epidemiological Study Assessing the Overuse of Proton Pump Inhibitors in Lebanese Population.
Epidemiological Study Assessing the Overuse of Proton Pump Inhibitors in Lebanese Population.
复制标题
流行病学研究评估黎巴嫩人口中质子泵抑制剂过度使用。
DOI：
10.34172/mejdd.2020.192
复制
发表时间：
2020-10
影响因子：
--
通讯作者：
Abou Rached A
中科院分区：
文献类型：
--
作者：
Hoteit M;Mattar E;Allaw R;Abou Rached A
背景质子泵抑制剂（PPI）是治疗大多数酸相关疾病的最有效的胃药。它们的有效性导致了过度使用，对患者造成潜在风险，并产生重大经济影响。 本研究的目的是确定黎巴嫩PPI过度使用的频率。因此，这种过度利用的经济影响，如果被证明是存在的，可以推断。 方法 一项流行病学描述性横断面研究在黎巴嫩各省的药店进行了为期一年的时间，使用问卷调查，1000名参与者前来购买PPI。因不适当的适应症或以不适当的剂量或持续时间服用PPI的受试者被视为滥用PPI。PPI适用于多种胃部疾病，并在服用胃毒性药物时预防胃肠道损伤。 结果 71.4%的受试者过度使用PPI。每年大约浪费2 500万美元。推断出三种类型的过度使用（适应症、剂量和持续时间）。胃保护是服用PPI的最常见原因。人口统计学变量和医生的处方并没有影响PPI的过度使用。 结论 PPI在黎巴嫩被大量过度使用，给医疗保健系统带来巨大负担。坚持循证指南和教育计划，强烈建议提高处方的质量和效率。
BACKGROUND Proton pump inhibitors (PPIs) are the most potent gastric agents for most acid-related disorders. Their effectiveness has led to their overutilization, leading to potential risks on patients and significant economic implications. The aim of this study was to determine the frequency of PPI overuse in Lebanon. Hence, the economic impact of this overutilization, if proven to be present, can be inferred. METHODS An epidemiological descriptive cross-sectional study was conducted in pharmacies all around Lebanese governorates over a 1-year period, using questionnaires handed out to 1000 participants coming to buy PPIs. Subjects taking PPIs for inappropriate indications or in inappropriate dosages or durations were considered abusing PPIs. PPIs are indicated for multiple gastric disorders and for prophylaxis of gastrointestinal injury when taking gastro-toxic medications. RESULTS 71.4% of subjects were overusing PPIs. Approximately 25 million US dollars were being wasted annually. Three categories of overuse were inferred (indication, dosage, and duration). Gastro protection was the most common reason for taking PPIs. Demographic variables and doctors’ prescriptions did not influence PPI overuse. CONCLUSION PPIs are massively overused in Lebanon, leading to a huge burden on the health care system. Adhering to evidence-based guidelines and educational programs is highly recommended to enhance the quality and efficiency of prescriptions.