Passive event-related potentials by a single tone in personality disorders
Passive event-related potentials by a single tone in personality disorders
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DOI：
10.2224/sbp.2008.36.7.985
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发表时间：
2008-01
影响因子：
1.3
通讯作者：
Yue-di Shen;Meifang Zhu;Dianchun Wang;Chundong Hao;J. Ma;Yongfu Cao;Ming Cao;W. Livesley;K. Jang;Wei Chen;M. Shen;Baihua Xu;Wen Wang
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文献类型：
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作者：
Yue-di Shen;Meifang Zhu;Dianchun Wang;Chundong Hao;J. Ma;Yongfu Cao;Ming Cao;W. Livesley;K. Jang;Wei Chen;M. Shen;Baihua Xu;Wen Wang
大脑P3电位（被动P3）对单音的反应与在主动“古怪”范式中引发的经典P3具有相似的形态，但反映的是被动注意。由于分裂型、反社会型和边缘型人格障碍患者表现为典型P3波幅减小和潜伏期延长，因此有理由认为这些患者可能表现为异常的被动P3。我们在205名人格障碍患者和30名健康志愿者中测试了单音是否引发了事件相关电位（erp）。采用Zung抑郁自评量表和焦虑自评量表（1966,1971）测量抑郁和焦虑I轴症状。精神分裂组和偏执组P3振幅均明显降低。分裂样神经组N1潜伏期明显缩短，N2振幅明显增强。除精神分裂外，大多数患者组在抑郁或焦虑量表上得分较高，或两者兼而有之，但ERP的发现与任何特定组的轴I症状无关。阴性成分的异常提示精神分裂患者具有较高的警觉性或皮层觉醒水平，P3振幅的降低提示精神分裂患者和偏执患者被动注意较差。
A cerebral P3 potential (passive P3) in response to a single tone shares similar morphology to the classical P3 elicited in the active “oddball” paradigm, but reflects passive attention. As patients with schizotypal, antisocial, and borderline personality disorders show reduced amplitude and prolonged latency of classical P3, it is reasonable to expect that these patients might show an abnormal passive P3. We tested whether the single tone elicited event-related potentials (ERPs) in 205 patients with personality disorders and in 30 healthy volunteers. Their Axis I symptoms of depression and anxiety were measured by Zung’s Self-rating Depression Scale and Self-rating Anxiety Scale (1965, 1971). Both schizoid and paranoid groups showed significantly reduced P3 amplitude. In addition, the schizoid group showed significantly shortened N1 latency and enhanced N2 amplitude. Most patient groups except schizoids scored higher on the Depression or Anxiety scales, or both, but the ERP findings were not correlated with the Axis I symptoms in any given group alone. The abnormal negative components implied a higher vigilance or cortical arousal level in the schizoid patients, while the reduced P3 amplitude indicated a poorer passive attention in both schizoid and paranoid patients.