Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus
Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus
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DOI：
10.1016/j.jneuroim.2010.03.018
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发表时间：
2010-06-01
影响因子：
3.3
通讯作者：
Reeves, Westley H.
中科院分区：
文献类型：
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作者：
Kellner, Erinn S.;Lee, Pui Y.;Reeves, Westley H.
系统性红斑狼疮（SLE）患者除了自身免疫性疾病的身体表现外，还经常患有抑郁和疲劳。在狼疮患者中已发现I型干扰素（IFN-I）的产生升高，并且IFN-I可引起多种神经精神副作用。本研究旨在评估狼疮患者IFN-Ⅰ产生失调与抑郁或疲劳之间的关系。通过横向和纵向分析，我们发现异常IFN-Ⅰ水平（通过外周血IFN-Ⅰ刺激基因表达测量）和神经精神症状之间没有显着的相关性。内源性血清IFN-I水平的升高不太可能解释与SLE相关的抑郁和疲劳。
Patients with systemic lupus erythematosus (SLE) often suffer from depression and fatigue in addition to the physical manifestations of the autoimmune disease. Elevated production of type-I interferons (IFN-I) has been found in lupus patients and IFN-I can precipitate a variety of neuropsychiatric side effects. This study was conducted to evaluate the relationship between dysregulated IFN-I production and the presence of depression or fatigue in lupus patients. Through cross-sectional and longitudinal analysis we found no significant correlation between abnormal IFN-I levels (as measured by peripheral blood expression of IFN-I-stimulated genes) and neuropsychiatric manifestations. Elevation of endogenous serum IFN-I levels is unlikely to account for the depression and fatigue associated with SLE.