Low Doses of Ethanol Enhance LTD-like Plasticity in Human Motor Cortex
Low Doses of Ethanol Enhance LTD-like Plasticity in Human Motor Cortex
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DOI：
10.1038/npp.2015.151
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发表时间：
2015-12-01
影响因子：
7.6
通讯作者：
Ziemann, Ulf
中科院分区：
文献类型：
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作者：
Fuhl, Anna;Mueller-Dahlhaus, Florian;Ziemann, Ulf
人类大量使用乙醇，因为它对社会交往有促进作用，但它对中枢神经系统功能的影响仍有待研究。我们最近描述了非常低剂量的乙醇消除了人类皮层中的长时程增强（LTP）样可塑性，最有可能是通过增强紧张性抑制[Lucke et al，2014，Neuropsychopharmacology 39：1508-18]。在这里，我们研究了低剂量乙醇对长时程抑郁（LTD）样可塑性的影响。采用配对联合经颅磁刺激（PAS（LTD））在人运动皮层诱发类LTD可塑性，以运动诱发电位输入-输出曲线（IO-曲线）的下降为指标。此外，通过扫视峰值速度（SPV）的降低来测量镇静。两种低剂量乙醇（EtOH
Humans liberally use ethanol for its facilitating effects on social interactions but its effects on central nervous system function remain underexplored. We have recently described that very low doses of ethanol abolish long-term potentiation (LTP)-like plasticity in human cortex, most likely through enhancement of tonic inhibition [Lucke et al, 2014, Neuropsychopharmacology 39:1508-18]. Here, we studied the effects of low-dose ethanol on long-term depression (LTD)-like plasticity. LTD-like plasticity was induced in human motor cortex by paired associative transcranial magnetic stimulation (PAS(LTD)), and measured as decreases of motor evoked potential input-output curve (IO-curve). In addition, sedation was measured by decreases in saccade peak velocity (SPV). Ethanol in two low doses (EtOH