Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors.
Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors.
复制标题
基于砜的核苷酸电子等排体的合成：CMP-唾液酸合成酶抑制剂的鉴定。
DOI：
10.1039/b819155g
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发表时间：
2009
影响因子：
3.2
通讯作者：
Gervay-Hague,Jacquelyn
中科院分区：
文献类型：
--
作者：
Wong,JessicaH;Sahni,Urvashi;Li,Yanhong;Chen,Xi;Gervay-Hague,Jacquelyn
公开了一种由核苷醛与双膦酸类Horner-Wadsworth-Emmons试剂缩合而成的磺基核苷酸类似物的模数取代合成方法。这些类似物被证明是脑膜炎奈瑟氏菌css(Nmcss)的抑制剂，Nmcss是细菌感染所需的荚膜多糖生物合成的关键酶。
A modular replacement approach to the synthesis of sulfo-nucleotide analogs prepared from condensation of nucleoside aldehydes with bis phosphonate Horner-Wadsworth-Emmons reagents is disclosed. These analogs were shown to be inhibitors of Neisseria meningitidis CSS (NmCSS), which is a key enzyme in the biosynthesis of the capsular polysaccharides required for bacterial infection.