Genetic basis to hybrid inviability is more complex than hybrid male sterility in Caenorhabditis nematodes
Genetic basis to hybrid inviability is more complex than hybrid male sterility in Caenorhabditis nematodes
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DOI：
10.1038/s41437-018-0069-y
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发表时间：
2018-08-01
期刊：
影响因子：
3.8
通讯作者：
Cutter, Asher D.
中科院分区：
文献类型：
--
作者：
Bundus, Joanna D.;Wang, Donglin;Cutter, Asher D.
杂交雄性不育往往在雌性不育或杂交种丧失之前进化，这意味着分离的谱系之间分歧的积累应该导致杂交雄性不育具有更多的基因基础。然而，实验证据是喜忧参半的。在这里，我们使用线虫线虫雷曼线虫和拉氏线虫来描述不对称杂交雄性不育和杂交丧失活力的潜在遗传基础。我们证明杂交种雄性不育符合简单的遗传基础，涉及单个X-常染色体不亲和性。我们还表明，杂交失活涉及更多的基因组区段，涉及不同的核-核不亲和性，有丝分裂-核不亲和性，以及母体效应。这些发现表明，与线虫杂交种的不生存能力相比，雄性对遗传扰动的敏感性在遗传上可能是简单的，并激发了对整个系统发育范围内杂交种不亲和性遗传结构的一般性测试。
Hybrid male sterility often evolves before female sterility or inviability of hybrids, implying that the accumulation of divergence between separated lineages should lead hybrid male sterility to have a more polygenic basis. However, experimental evidence is mixed. Here, we use the nematodes Caenorhabditis remanei and C. latens to characterize the underlying genetic basis of asymmetric hybrid male sterility and hybrid inviability. We demonstrate that hybrid male sterility is consistent with a simple genetic basis, involving a single X-autosome incompatibility. We also show that hybrid inviability involves more genomic compartments, involving diverse nuclear-nuclear incompatibilities, a mito-nuclear incompatibility, and maternal effects. These findings demonstrate that male sensitivity to genetic perturbation may be genetically simple compared to hybrid inviability in Caenorhabditis and motivates tests of generality for the genetic architecture of hybrid incompatibility across the breadth of phylogeny.