Parkinson's disease and cancer: A register-based family study.
Parkinson's disease and cancer: A register-based family study.
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帕金森病和癌症：基于登记的家庭研究。
DOI：
10.1093/aje/kwt232
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发表时间：
2014
影响因子：
5
通讯作者：
Ye,Weimin
中科院分区：
文献类型：
--
作者：
Wirdefeldt,Karin;Weibull,CarolineE;Chen,Honglei;Kamel,Freya;Lundholm,Cecilia;Fang,Fang;Ye,Weimin
我们想比较帕金森病（PD）患者和非PD患者以及这些患者的兄弟姐妹之间的癌症发病率。我们进行了一项基于家庭的匹配队列研究，该研究基于瑞典全国健康登记处和瑞典多代登记处。我们评估了1964-2009年期间PD患者（n= 11，786）与无PD个体（n= 58，930）匹配队列以及PD患者的兄弟姐妹（n= 16，841）与无PD个体的兄弟姐妹（n= 84，205）的癌症发病风险。使用考克斯比例风险回归估计风险比和95%置信区间。PD患者的癌症发生率略高于无PD个体（风险比（HR）= 1.05，95%置信区间（CI）：1.00，1.10），主要是因为PD索引日期之前或之后1年内发生的癌症，但吸烟相关癌症的风险较低（HR = 0.87，95% CI：0.79，0.96）。PD患者在PD索引日期前1年（HR = 1.53，95% CI：1.23，1.91）和索引日期后1年（HR = 1.46，95% CI：1.01，2.10）的黑色素瘤风险较高。在同胞比较中，癌症的发生率基本相似。这些结果表明，黑色素瘤的风险是更高的PD患者和机制以外的家族性解释的关联。
We wanted to compare cancer incidence rates between Parkinson's disease (PD) patients and persons without PD, as well as between siblings of these groups. We conducted a family-based matched cohort study based on nationwide Swedish health registries and the Swedish Multi-Generation Register. We assessed risk of incident cancer in PD patients (n= 11,786) during 1964–2009 versus a matched cohort of PD-free individuals (n= 58,930) and in siblings of PD patients (n= 16,841) versus siblings of PD-free individuals (n= 84,205). Hazard ratios with 95% confidence intervals were estimated using Cox proportional hazards regression. Cancer occurrence was slightly higher in PD patients than in PD-free individuals (hazard ratio (HR) = 1.05, 95% confidence interval (CI): 1.00, 1.10), largely because of cancers arising within 1 year before or after the index date for PD, but risk of smoking-related cancers was lower (HR = 0.87, 95% CI: 0.79, 0.96). PD patients had a higher risk of melanoma both up to 1 year before the PD index date (HR = 1.53, 95% CI: 1.23, 1.91) and from 1 year after the index date onward (HR = 1.46, 95% CI: 1.01, 2.10). In the sibling comparison, cancer occurrence was largely similar. These results indicate that melanoma risk is higher among PD patients and that mechanisms other than familial ones explain the association.