Effect of soluble corn fiber supplementation for 1 year on bone metabolism in children, the MetA-bone trial: Rationale and design.
Effect of soluble corn fiber supplementation for 1 year on bone metabolism in children, the MetA-bone trial: Rationale and design.
复制标题
补充可溶性玉米纤维 1 年对儿童骨代谢的影响，MetA-骨试验：基本原理和设计。
DOI：
10.1016/j.cct.2020.106061
复制
发表时间：
2020
影响因子：
2.2
通讯作者：
Weaver,CM
中科院分区：
文献类型：
--
作者：
Palacios,C;Trak-Fellermeier,MA;Pérez,CM;Huffman,F;HernandezSuarez,Y;Bursac,Z;Gambon,TB;Nakatsu,CH;Weaver,CM
钙的摄入对青春期足够的骨矿化至关重要，但在美国青少年中通常是不足的。最大化骨矿化的一个策略是增加钙的吸收，这可以通过可溶性玉米纤维（SCF）来实现。目前还没有研究确定SCF对儿童骨量的长期影响。目的：与安慰剂相比，确定1年SCF补充对低钙习惯性摄入儿童骨量和骨生物标志物的影响。我们假设补充SCF会导致更高的骨矿物质含量和更高的骨形成水平，以及更低的骨吸收生物标志物。方法240例健康儿童（10-13 岁），正常低钙摄取量，随机分为4个实验组，为期1 年：(1)SCF(12 g/d)；(2) SCF（12 g/d） + 600 mg/d；(3)安慰剂（麦芽糊精）；(4)安慰剂+600 mg/d钙。这些补充剂已经与调味粉末饮料预先混合，参与者只需要在水中稀释，每天喝两次。在基线、6和12 个月时使用双能x线骨密度仪（DXA）测量骨骼。血清骨生物标志物将在基线和12 个月时进行测量。结论：如果在饮食中添加SCF可以提高青春期的骨量，这有助于实现PBM的遗传潜力，并以更强壮的骨骼开始成年生活。如果成功，可将SCF纳入青少年的饮食中，以促进骨骼健康。
Calcium intake is critical for adequate bone mineralization in adolescence, but it is usually inadequate in US adolescents. A strategy to maximize bone mineralization is to increase calcium absorption, which could be achieved by soluble corn fiber (SCF). There are no studies determining the long-term effects of SCF on bone mass in children.ObjectivesTo determine the effect of one-year SCF supplementation compared to placebo on bone mass and bone biomarkers in children with low habitual calcium intake. We hypothesize that SCF supplementation will result in a higher bone mineral content and higher levels of bone formation and lower bone resorption biomarkers.Methods240 healthy children (10–13 years), with usual low calcium intake, will be randomized to four experimental groups for 1 year: (1) SCF (12 g/d); (2) SCF (12 g/d) + 600 mg/d of calcium; (3) Placebo (maltodextrin); and (4) Placebo +600 mg/d of calcium. The supplements have been pre-mixed with a flavored powder beverage and participants will only need to dilute it in water and drink this twice per day. Bone will be measured using dual energy x-ray absorptiometry (DXA) at baseline, 6 and 12 months. Serum bone biomarkers will be measured at baseline and at 12 months.ConclusionsIf supplementing diets with SCF lead to higher bone mass during adolescence, this could help achieve the genetic potential for PBM and to start adult life with stronger bones. If successful, SCF can be incorporated into diets for promoting bone health in adolescents.