Mother-to-child HIV transmission in a cohort of pregnant women diagnosed by rapid HIV testing at Tijuana General Hospital, Baja California, Mexico.
Mother-to-child HIV transmission in a cohort of pregnant women diagnosed by rapid HIV testing at Tijuana General Hospital, Baja California, Mexico.
复制标题
DOI：
10.1177/1545109710363920
复制
发表时间：
2010-03-01
期刊：
影响因子：
--
通讯作者：
Spector, Stephen A
中科院分区：
文献类型：
--
作者：
Viani, Rolando M;Ruiz-Calderon, Jorge;Spector, Stephen A
本研究评估了墨西哥下加利福尼亚州一项使用快速 HIV 检测预防 HIV 母婴传播 (MTCT) 的产科计划。 2003年至2005年间，45名待产妇女和17名产前护理妇女感染了艾滋病毒。在待产患者中，有 14 名 (31%) 是通过剖腹产分娩的，而产前护理患者中有 17 名 (100%) (P < .001)。与待产患者相比，产前护理中孕妇静脉注射齐多夫定 (ZDV) 和婴儿口服 ZDV 的频率更高：分别为 94% 与 33% (P < .001) 和 100% 与 79% (P < .001)。所有产前护理妇女均接受联合治疗。所有 10 名 HIV 感染婴儿均属于待产组，因此母婴传播率为 23%（95% 置信区间 [CI] 9.5-34.8），而产前护理组的母婴传播率为 0%（95% CI 0-1.8；P < .001）。 5 名 (50%) 感染艾滋病毒的婴儿被诊断为艾滋病，其中 2 名 (20%) 在出生后 18 个月内死亡。在分娩过程中被诊断出的妇女的艾滋病毒母婴传播率较高，且产后结局较差。
This study evaluated an obstetrical program using rapid HIV testing for the prevention of mother-to-child HIV transmission (MTCT) in Baja California, Mexico. Between 2003 and 2005, 45 women in labor and 17 prenatal care women were HIV infected. Among labor patients, 14 (31%) delivered by cesarean section compared with 17 (100%) prenatal care patients (P < .001). Intravenous maternal zidovudine (ZDV) and infant oral ZDV were more frequently administered in prenatal care compared to labor patients: 94% versus 33% (P < .001) and 100% versus 79% (P < .001), respectively. All prenatal care women received combination therapy. All 10 HIV-infected infants were in the labor group, resulting in a MTCT rate of 23% (95% confidence interval [CI] 9.5-34.8) compared to 0% (95% CI 0-1.8; P < .001) among the prenatal care group. Five (50%) of the HIV-infected infants had an AIDS diagnosis and 2 (20%) died within 18 months of birth. Women diagnosed during labor had a high HIV MTCT and poor postnatal outcome.