DISULFIDE BRIDGES IN NH2-TERMINAL PART OF HUMAN FIBRINOGEN
DISULFIDE BRIDGES IN NH2-TERMINAL PART OF HUMAN FIBRINOGEN
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DOI：
10.1016/0049-3848(76)90245-0
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发表时间：
1976-01-01
影响因子：
7.5
通讯作者：
HOGG, D
中科院分区：
文献类型：
--
作者：
BLOMBACK, B;HESSEL, B;HOGG, D
与CNBr裂解得到的纤维蛋白原（N-DSK）的nh2末端为二聚体结构（m.w.58000）。N-DSK的半分子显然是由a - α中的对称二硫桥连接在一起的。-和-链。因此，纤维蛋白原的两个半分子以相同的方式连接。此外，N-DSK在其半分子内含有链间二硫桥。展示了这些桥梁的布置，并讨论了与功能相关的几何结构。
The NH2-terminal portion of fibrinogen (N-DSK) obtained by cleavage with CNBr was a dimeric structure (M.W. 58,000). The half-molecules of N-DSK were apparently held together by symmetrical disulfide bridges in its A.alpha.- and .gamma.-chains. Consequently the 2 half-molecules of fibrinogen were linked in the same way. In addition, N-DSK contained inter chain disulfide bridges within its half-molecules. The arrangement of these bridges was shown and the geometry in relation to function discussed.