Oscillatory coupling in writing and writer's cramp
Oscillatory coupling in writing and writer's cramp
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DOI：
10.1016/j.jphysparis.2005.06.003
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发表时间：
2006-01-01
影响因子：
--
通讯作者：
Schnitzler, A
中科院分区：
文献类型：
--
作者：
Butz, M;Timmermann, L;Schnitzler, A
写作是一项技术高超、学识渊博的运动。作家痉挛是一种局灶性任务诱发的肌张力障碍，在患者一拿起笔或写几个字的时候，由于不自觉的肌肉收缩和异常姿势，写作就会受到损害，甚至不能写作，这种运动障碍的潜在病理生理机制到目前为止还没有完全了解。本研究旨在揭示正常人生理性书写和作家痉挛患者书写障碍的振荡网络。采用全头脑磁图(MEG)和相干源动态成像(DICS)分析工具，对11名健康受试者和8例作家痉挛患者写作过程中的振荡神经耦合进行了研究。同时记录受试者用优势右手写字5min时的脑电活动和前臂、手部肌肉活动。应用DICS，在写作过程中确定了最强的大脑-肌肉一致性和大脑-大脑一致性来源，在对照组和患者中一致地包括六个脑区：对侧和同侧感觉运动皮质，同侧小脑，对侧丘脑，对侧运动前和后顶叶皮质。皮层来源和肌肉来源之间的一致性主要出现在书写动作的频率(3-7赫兹)上，而大脑来源之间的一致性主要出现在10赫兹(813赫兹)左右。有趣的是，仅在患者的双侧感觉运动皮质之间观察到一致的耦合，而在对照受试者中仅发现同侧小脑和对侧顶后皮质之间的耦合。这些结果与作家痉挛患者经常描述的双侧病理生理和感觉运动整合受损相一致。(C)2005爱思唯尔有限公司。保留所有权利。
Writing is a highly skilled and overlearned movement. In patients suffering from writer's cramp, a focal task-induced dystonia, writing is impaired or even impossible due to involuntary muscle contractions and abnormal posture, which occur as soon as the person picks up a pen or within writing a few words, The underlying pathophysiological mechanisms of this movement disorder are not fully understood up to now. The aim of the present study was to unravel the oscillatory network underlying physiological writing in healthy subjects and dystonic writing in writer's cramp patients.Using whole-head magnetoencephalography (MEG) and the analysis tool dynamic imaging of coherent sources (DICS) we studied oscillatory neural coupling during writing in eleven healthy subjects and eight patients suffering from writer's cramp. Simultaneous recording of brain activity with MEG and activity of forearm and hand muscles with surface electromyography (EMG) was performed while subjects were writing for five minutes with their dominant right hand. Applying DICS sources of strongest cerebro-muscular coherence and cerebro-cerebral coherence during writing were identified, which consistently included six brain areas in both, the control subjects and the patients: contralateral and ipsilateral sensorimotor cortex, ipsilateral cerebellum, contralateral thalamus, contralateral premotor and posterior parietal cortex. Coherence between cortical sources and muscles appeared primarily in the frequency of writing movements (3-7 Hz) while coherence between cerebral sources occurred primarily around 10 Hz (813 Hz). Interestingly, consistent coupling between both sensorimotor cortices was observed in patients only, whereas coupling between ipsilateral cerebellum and the contralateral posterior parietal cortex was found in control subjects only.These results are consistent with the often described bilateral pathophysiology and impaired sensorimotor integration in writer's cramp patients. (c) 2005 Elsevier Ltd. All rights reserved.