Cytomegalovirus infection accelerates epigenetic aging
Cytomegalovirus infection accelerates epigenetic aging
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DOI：
10.1016/j.exger.2015.10.008
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发表时间：
2015-12-01
影响因子：
3.9
通讯作者：
Hurme, Mikko
中科院分区：
文献类型：
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作者：
Kananen, Laura;Nevalainen, Tapio;Hurme, Mikko
表观遗传机制如DNA甲基化（DNAm）在基因表达的调节中具有中心作用，从而在细胞分化和组织稳态中具有中心作用。最近的研究表明，衰老与DNAm的深刻变化有关。这些甲基化变化中的一些以时钟样的方式发生，即与个体的日历年龄相关。因此，基于这种DNAm变化的表观遗传时钟可以为人类衰老过程提供一种新的生物标志物，即能够将日历和生物年龄分开。关于这个时钟所指示的时间与免疫衰老的各个方面的相关性的信息仍然缺失。由于慢性巨细胞病毒（CMV）感染可能是免疫衰老的主要驱动力之一，我们现在已经分析了CMV血清阳性与1920年Vitality 90+队列中表观遗传年龄的相关性（122名90岁以上老人和21名年轻对照，CMV血清阳性率分别为95%和57%）。数据显示，在这两个年龄组中，CMV血清阳性与较高的表观遗传年龄相关（年轻对照组的中位数为26.5 vs. 24.0（p < 0.02，Mann-Whitney U检验），90岁以上对照组的中位数为76.0 vs. 70.0（p < 0.01））。因此，这些数据为CMV相关的病理过程提供了一个新的方面。(C)2015 Elsevier Inc. All rights reserved.
Epigenetic mechanisms such as DNA methylation (DNAm) have a central role in the regulation of gene expression and thereby in cellular differentiation and tissue homeostasis. It has recently been shown that aging is associated with profound changes in DNAm. Several of these methylation changes take place in a clock-like fashion, i.e. correlating with the calendar age of an individual. Thus, the epigenetic clock based on these kind of DNAm changes could provide a new biomarker for human aging process, i.e. being able to separate the calendar and biological age. Information about the correlation of the time indicated by this clock to the various aspects of immunosenescence is still missing. As chronic cytomegalovirus (CMV) infection is probably one of the major driving forces of immunosenescence, we now have analyzed the correlation of CMV seropositivity with the epigenetic age in the Vitality 90+ cohort 1920 (122 nonagenarians and 21 young controls, CMV seropositivity rates 95% and 57%, respectively). The data showed that CMV seropositivity was associated with a higher epigenetic age in both of these age groups (median 26.5 vs. 24.0 (p < 0.02, Mann-Whitney U-test) in the young controls and 76.0 vs. 70.0 (p < 0.01) in the nonagenarians). Thus, these data provide a new aspect to the CMV associated pathological processes. (C) 2015 Elsevier Inc. All rights reserved.