Gingival crevicular fluid as a source of biomarkers for periodontitis.
Gingival crevicular fluid as a source of biomarkers for periodontitis.
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DOI：
10.1111/prd.12107
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发表时间：
2016-02
影响因子：
18.6
通讯作者：
Morelli T
中科院分区：
文献类型：
--
作者：
Barros SP;Williams R;Offenbacher S;Morelli T
在评估牙周病的发病机制，龈沟液的诊断潜力已被广泛探讨，在过去的二十年中，从最初只是确认健康和疾病状态，最近调查它作为一个潜在的预后工具。由于宿主易感性是牙周病发病机制的关键决定因素，龈沟液中存在的炎症介质水平代表了疾病活动的相关风险指标。已经进行了大量的工作，以确定许多不同的细胞因子，炎症途径和微生物刺激与牙周病的发病机制。现在，“组学”方法旨在总结这些途径如何相互作用，并可能汇合以创建关键的炎症网络。最近，龈沟液代谢组学似乎有希望作为一个额外的诊断方法。生物膜结构和宿主对微生物挑战的炎症反应可诱导特异性炎症特征。宿主遗传学和表观遗传学也可能调节微生物定植，增加了潜在因果途径的多样性。龈沟液的组学分析，测量与牙周病的发病和进展相关的微生物和宿主相互作用，仍然显示出扩大诊断，预后和治疗标志物发现的前景的潜力。
In evaluating the pathogenesis of periodontal diseases, the diagnostic potential of gingival crevicular fluid has been extensively explored during the last twenty years, from initially just confirming health and disease states to more recently investigating it as a potential prognostic tool. As host susceptibility is a critical determinant in periodontal disease pathogenesis, the inflammatory mediator levels present in gingival crevicular fluid represent relevant risk indicators for disease activity. Considerable work has been carried out to identify the many different cytokine inflammatory pathways and microbial stimuli that are associated with periodontal disease pathogenesis. Now, ‘omics’ approaches aim to summarize how these pathways interact and probably converge to create critical inflammatory networks. More recently, gingival crevicular fluid metabolomics appears promising as an additional diagnostic method. Biofilm structure and the host inflammatory response to the microbial challenge may induce specific inflammatory signatures. Host genetics and epigenetics may also modulate microbial colonization, adding to the multiplicity of potential causal pathways. Omics analyses of gingival crevicular fluid, measuring microbial and host interactions in association with the onset and progression of periodontal diseases, still show the potential to expand the landscape for the discovery of diagnostic, prognostic and therapeutic markers.