The role of gut-liver axis in the pathogenesis of liver cirrhosis and portal hypertension.
The role of gut-liver axis in the pathogenesis of liver cirrhosis and portal hypertension.
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DOI：
10.3350/cmh.2012.18.4.337
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发表时间：
2012-12
影响因子：
8.9
通讯作者：
Shah VH
中科院分区：
文献类型：
--
作者：
Seo YS;Shah VH
由于解剖位置和其独特的血管系统，肝脏容易暴露于来自肠道的微生物产物。尽管大量微生物在肠道中定殖，但在健康受试者中，肠道上皮屏障功能和肝脏的清洁和解毒功能阻止了微生物或微生物产物易位到肝脏和体循环中。然而，当肠道屏障功能被破坏时，大量的细菌产物可以进入肝脏和体循环，并通过其受体诱导炎症。目前，已有多项研究表明肠道植物群和细菌移位在慢性肝病和门静脉高压症的发病机制中的作用。本文就细菌移位及其在慢性肝病和门静脉高压症发病机制中的作用作一综述。
Because of the anatomical position and its unique vascular system, the liver is susceptible to the exposure to the microbial products from the gut. Although large amount of microbes colonize in the gut, translocation of the microbes or microbial products into the liver and systemic circulation is prevented by gut epithelial barrier function and cleansing and detoxifying functions of the liver in healthy subjects. However, when the intestinal barrier function is disrupted, large amount of bacterial products can enter into the liver and systemic circulation and induce inflammation through their receptors. Nowadays, there have been various reports suggesting the role of gut flora and bacterial translocation in the pathogenesis of chronic liver disease and portal hypertension. This review summarizes the current knowledge about bacterial translocation and its contribution to the pathogenesis of chronic liver diseases and portal hypertension.