Biomarkers for early detection of colon cancer.
Biomarkers for early detection of colon cancer.
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发表时间：
2001-05
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通讯作者：
S. Srivastava;M. Verma;Donald E. Henson
中科院分区：
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作者：
S. Srivastava;M. Verma;Donald E. Henson
对结肠癌生物标志物用于风险评估、早期检测、预后和替代终点的需求不断增加。尽管尚未广泛确定危险因素，但已鉴定出许多用于早期检测结肠癌的生物标志物。了解结直肠癌的主要进展包括 APC、p53 和 Ki-ras 在疾病发生和进展中的识别和参与、异常隐窝病灶作为早期浸润前病变的识别及其与癌症发展的关系。早期检测恶性肿瘤具有临床优势；因此，国家癌症研究所建立了一个早期检测研究网络：该网络的重点是科学家之间的转化研究和合作。
There is an increasing demand for biomarkers in colon cancer for risk assessment, early detection, prognosis, and surrogate end points. A number of biomarkers have been identified for early detection of colon cancer, although the risk factors have not been identified extensively. The major advances in understanding colorectal cancer include the identification and the involvement of APC, p53, and Ki-ras in the development and progression of the disease, the identification of the aberrant crypt foci as an early preinvasive lesion, and its relation to the development of cancer. Detecting malignant neoplasms in the early stages offers clinical advantages; therefore, the National Cancer Institute has established an Early Detection Research NETWORK: The emphasis of the network is on translational research and collaboration among scientists.