Tertiary Lymphoid Organs in Cancer Tissues.
Tertiary Lymphoid Organs in Cancer Tissues.
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DOI：
10.3389/fimmu.2016.00244
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发表时间：
2016
影响因子：
7.3
通讯作者：
Yamazaki-Itoh R
中科院分区：
文献类型：
--
作者：
Hiraoka N;Ino Y;Yamazaki-Itoh R
第三淋巴器官(TLO)是出生后在非淋巴组织中诱导的，如慢性感染、自身免疫性疾病和慢性同种异体移植排斥反应的影响，也包括癌症组织。Tlos被认为为细胞免疫和体液免疫提供重要的淋巴细胞功能环境，类似于淋巴结节或Peyer‘s斑块。其结构类似于淋巴结或Peyer‘s斑块，包括T细胞区、B细胞滤泡和无包膜的高内皮微静脉(HEV)。在这里，我们回顾了我们对人类实体癌中TLO的最新知识进展，包括它们的位置、结构、评估方法和临床病理影响。我们还讨论了肿瘤组织中TLO的形成和/或维持与肿瘤免疫微环境、肿瘤侵袭和肿瘤间质组织结构的关系。
Tertiary lymphoid organs (TLOs) are induced postnatally in non-lymphoid tissues such as those affected by chronic infections, autoimmune diseases, and chronic allograft rejection, and also in cancer tissues. TLOs are thought to provide important lymphocytic functional environments for both cellular and humoral immunity, similar to lymph nodes or Peyer’s patches. TLOs have a structure similar to that of lymph nodes or Peyer’s patches, including T cell zones, B cell follicles, and high endothelial venules (HEV) without encapsulation. Here, we review recent advances in our knowledge of TLOs in human solid cancers, including their location, structure, methods of evaluation, and clinicopathological impact. We also discuss the formation and/or maintenance of TLOs in cancer tissues in association with the tumor immune microenvironment, cancer invasion, and the tissue structure of the cancer stroma.