Strain-derived canalicular fluid flow regulates osteoclast activity in a remodelling osteon - a proposal
Strain-derived canalicular fluid flow regulates osteoclast activity in a remodelling osteon - a proposal
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DOI：
10.1016/s0021-9290(03)00126-x
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发表时间：
2003-10-01
影响因子：
2.4
通讯作者：
Smit, TH
中科院分区：
文献类型：
--
作者：
Burger, EH;Klein-Nulend, J;Smit, TH
由基本的多细胞单位进行骨重塑的概念已经确立，但吸收破骨细胞如何通过预先存在的骨基质找到它们的方式仍未得到解释。次级骨沿主要加载方向的排列表明，重塑是由机械应变引导的。这意味着适应（沃尔夫定律）发生在生命的每个重塑周期中。我们认为，在重塑过程中，由于切割锥周围的不同管状流模式和加载期间的反转区，会发生对准。切割锥尖端周围的低管流被认为可以减少局部骨细胞的NO产生，从而导致其凋亡。反过来，骨细胞凋亡可能是吸引破骨细胞的机制，导致骨在加载方向进一步挖掘。然而，在切割锥和逆转区之间的过渡阶段，小管血流增强将刺激骨细胞增加NO的产生，从而诱导破骨细胞从骨表面缩回和脱离。总之，这导致了在切割锥的尖端和外围分别附着和分离破骨细胞的跑步机，并在加载方向上挖掘了一个隧道。(C) 2003年Elsevier Science Ltd.出版
The concept of bone remodelling by basic multicellular units is well established, but how the resorbing osteoclasts find their way through the pre-existing bone matrix remains unexplained. The alignment of secondary osteons along the dominant loading direction suggests that remodelling is guided by mechanical strain. This means that adaptation (Wolff's Law) takes place throughout life at each remodelling cycle. We propose that alignment during remodelling occurs as a result of different canalicular flow patterns around cutting cone and reversal zone during loading. Low canalicular flow around the tip of the cutting cone is proposed to reduce NO production by local osteocytes thereby causing their apoptosis. In turn, osteocyte apoptosis could be the mechanism that attracts osteoclasts, leading to further excavation of bone in the direction of loading. At the transition between cutting cone and reversal zone, however, enhanced canalicular flow will stimulate osteocytes to increase NO production, which induces osteoclast retraction and detachment from the bone surface. Together, this leads to a treadmill of attaching and detaching osteoclasts in the tip and the periphery of the cutting cone, respectively, and the digging of a tunnel in the direction of loading. (C) 2003 Published by Elsevier Science Ltd.