To engraft or not to engraft: an ecological framework for gut microbiome modulation with live microbes.
To engraft or not to engraft: an ecological framework for gut microbiome modulation with live microbes.
复制标题
移植或不移植：用活微生物调节肠道微生物组的生态框架。
DOI：
10.1016/j.copbio.2017.08.008
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发表时间：
2018
影响因子：
7.7
通讯作者：
Martínez,Inés
中科院分区：
文献类型：
--
作者：
Walter,Jens;Maldonado-Gómez,MaríaX;Martínez,Inés
亮点通过活微生物调节微生物群在改善健康方面具有巨大潜力。最近的研究为活微生物对肠道微生物群的影响提供了新的见解。生态理论可以帮助对微生物群调节干预措施的影响达成概念性理解。生态学视角对于改进现有策略和开发新策略至关重要。旨在利用活微生物调节肠道微生物群的策略范围从单一菌株（益生菌或活生物治疗药物）到整体未定义的粪便移植。尽管通常在临床上有效，但我们对基于微生物的策略如何调节肠道微生物组组成和功能的理解还很不完整。在这篇综述中，我们提出了一个基于生态理论的框架，该框架为试图利用活微生物调节人类和动物肠道微生物群的研究中获得的结果提供了机制解释。我们认为，基于理论的生态视角对于解释和预测微生物组调节策略的影响是必要的，从而提高我们开发改进的、有针对性的方法并提高治疗效率的能力。
HighlightsMicrobiome-modulation through live microbes has enormous potential to improve health.Recent studies have provided new insights into the impact of live microbes on gut microbiomes.Ecological theory can help reach a conceptual understanding on the impact of microbiome-modulating interventions.An ecological perspective will be essential to improve currently available strategies and develop novel ones.Strategies aimed at modulating the gut microbiota by using live microbes range from single strains (probiotics or live biotherapeutics) to whole non-defined fecal transplants. Although often clinically efficacious, our understanding on how microbial-based strategies modulate gut microbiome composition and function is vastly incomplete. In this review, we present a framework based on ecological theory that provides mechanistic explanations for the findings obtained in studies that attempted to modulate the gut microbiota of humans and animals using live microbes. We argue that an ecological perspective grounded in theory is necessary to interpret and predict the impact of microbiome-modulating strategies and thus advance our ability to develop improved and targeted approaches with enhanced therapeutic efficiency.