Stage-specific expression of microRNAs during Xenopus development
Stage-specific expression of microRNAs during Xenopus development
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DOI：
10.1016/j.febslet.2004.11.067
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发表时间：
2005-01-17
期刊：
影响因子：
3.5
通讯作者：
Imai, H
中科院分区：
文献类型：
--
作者：
Watanabe, T;Takeda, A;Imai, H
microRNAs（miRNAs）在转录后水平抑制靶基因，在细胞发育和谱系决定中发挥重要作用。然而，在脊椎动物中，miRNAs的靶标及其在发育过程中的表达谱都知之甚少。在这里，我们报告了非洲爪蟾从卵母细胞阶段到蝌蚪阶段的miRNAs的详细表达谱。随着发育的进行，各种miRNA开始表达。大多数miRNAs出现在特定的阶段，并持续表达，直到蝌蚪阶段。此外，我们发现了一种新的miRNA，它只在发育的特定阶段表达，可能在中囊胚过渡中发挥作用。(C)2004年欧洲生物化学学会联合会。Elsevier B.V.出版，保留所有权利。
MicroRNAs (miRNAs) repress target genes at the post-transcriptional level and play important roles in development and cell lineage decision. However, in vertebrates, both the targets of miRNAs and their expression profile during development are poorly understood. Here, we report the detailed expression profiles of miRNAs from oocyte stage to tadpole stage in Xenopus laevis. As development proceeds, a variety of miRNAs start to be expressed. Most miRNAs emerged at a specific stage and were continuously expressed until the tadpole stage. In addition, we identified a novel miRNA that was expressed only at specific stages of development and that is likely to have roles in midblastula transition. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.