ACUTE PHASE-SHIFTING EFFECTS OF MELATONIN ASSOCIATED WITH SUPPRESSION OF CORE BODY-TEMPERATURE IN HUMANS
ACUTE PHASE-SHIFTING EFFECTS OF MELATONIN ASSOCIATED WITH SUPPRESSION OF CORE BODY-TEMPERATURE IN HUMANS
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DOI：
10.1016/0304-3940(94)90282-8
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发表时间：
1994-08-29
影响因子：
2.5
通讯作者：
ARENDT, J
中科院分区：
文献类型：
--
作者：
DEACON, S;ENGLISH, J;ARENDT, J
适当施用褪黑激素能够改变昼夜节律，引起短暂的睡意并抑制核心体温。这些现象之间的关系尚未得到充分探索。在一项双盲、安慰剂对照的交叉研究中，8 名健康男性在自然环境中始终保持规律的睡眠-觉醒周期。从黄昏到第 2400 小时（D），1-4 名受试者在 2400-0800 小时处于昏暗的人工照明（< 100 勒克斯）和黑暗（< 1 勒克斯）中。白天外出时戴太阳镜。第 3 天 1700 小时时，服用褪黑激素（5 毫克）或安慰剂。在第 3 天和第 4 天的 1600-2400 小时，每隔 30 分钟采集唾液样本，并在第 3 天的 1600-2400 小时，每隔 30 分钟采集一次唾液样本，并在第 4 天的 0800-2400 小时，每小时评估主观警觉性。在第 2、3 和 4 晚评估睡眠质量，并全程记录核心温度。褪黑激素显着抑制体温，并在给药后 2.5 小时达到峰值，同时改善第 3 天晚上的睡眠质量，并在第 4 天使内源性褪黑激素节律提前。在 7 名可检测到褪黑激素的受试者中，有 6 名受试者的相移程度与温度抑制量相关，这表明温度抑制是相移机制的一个组成部分。
Appropriately administered melatonin is able to phase shift circadian rhythms, to induce transient sleepiness and to suppress core body temperature. The relationships between these phenomena have not been fully explored. In a double-blind, placebo-controlled crossover study, 8 healthy males maintained a regular sleep-wake cycle in a natural environment throughout. From dusk until 2400 h on days (D) 1-4 subjects were in dim artificial lighting (< 100 lux) with darkness (< 1 lux) from 2400-0800 h. Sunglasses were worn during the day when outside. At 1700h on D3 either melatonin (5 mg) or placebo was administered. Saliva samples were collected at 30 min intervals, 1600-2400 h on D3 and D4, and subjective alertness rated at 30 min intervals from 1600-2400 h on D3 and hourly From 0800-2400 h D4. Sleep quality was rated on nights 2, 3 and 4 and core temperature was recorded throughout. Melatonin induced a significant suppression of temperature and alertness peaking 2.5 h after the dose, together with improved sleep quality on the night of D3 and a phase advance of the endogenous melatonin rhythm on D4. The degree of phase shift was related to the amount of temperature suppression in 6 of 7 subjects with detectable melatonin, suggesting that temperature suppression is an integral part of the phase-shifting mechanism.