Inhibitory effects of 1,3-selenazol-4-one derivatives on mushroom tyrosinase
Inhibitory effects of 1,3-selenazol-4-one derivatives on mushroom tyrosinase
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DOI：
10.1248/cpb.50.1594
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发表时间：
2002-12-01
影响因子：
1.7
通讯作者：
Kim, SY
中科院分区：
文献类型：
--
作者：
Koketsu, M;Choi, SY;Kim, SY
本研究报道了1,3-硒唑-4-酮衍生物的脱色效力，这将基于发现对蘑菇酪氨酸酶的直接抑制。1,3-硒化唑-4-酮衍生物对蘑菇酪氨酸酶的多巴氧化酶活性有抑制作用。本文研究了6种1,3-硒化唑-4-酮衍生物（A、B、C、D、E和F）对蘑菇酪氨酸酶的抑制作用。500 μ m浓度的化合物对蘑菇酪氨酸酶多巴氧化酶活性的抑制作用为33.4 ~ 62.1%。它们的抑制作用高于著名的酪氨酸酶抑制剂曲酸（31.7%）。2-（4-甲基苯基）-1,3-selenazol-4-one (A)表现出较强的剂量依赖性和竞争性抑制作用。
This study reports depigmenting potency of 1,3-selenazol-4-one derivatives, which would be based upon the finding of direct inhibition to mushroom tyrosinase. 1,3-Selenazol-4-one derivatives exhibited inhibitory effect on dopa oxidase activity of mushroom tyrosinase. In this study, inhibitory effects of six kinds of 1,3-selenazol-4-one derivatives (A, B, C, D, E and F) on mushroom tyrosinase were investigated. Compounds at a concentration of 500 mum exhibited 33.4-62.1% of inhibition on dopa oxidase activity of mushroom tyrosinase. Their inhibitory effects were higher than that of kojic acid (31.7%), a well known tyrosinase inhibitor. 2-(4-Methylphenyl)-1,3-selenazol-4-one (A) exhibited the strongest inhibitory effect among them dose-dependently and in competitive inhibition manner.