Predictors of polycyclic aromatic hydrocarbon exposure and internal dose in inner city Baltimore children.
Predictors of polycyclic aromatic hydrocarbon exposure and internal dose in inner city Baltimore children.
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巴尔的摩市中心儿童多环芳烃暴露和内部剂量的预测因素。
DOI：
10.1038/jes.2016.57
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发表时间：
2017
影响因子：
4.5
通讯作者：
Strickland,PaulT
中科院分区：
文献类型：
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作者：
Peters,KamauO;Williams,D'AnnL;Abubaker,Salahadin;Curtin-Brosnan,Jean;McCormack,MeredithC;Peng,Roger;Breysse,PatrickN;Matsui,ElizabethC;Hansel,NadiaN;Diette,GregoryB;Strickland,PaulT
多环芳烃 (PAH) 是有机材料不完全燃烧的副产品，常见于颗粒物 (PM) 中，与城市人口哮喘的发生和哮喘恶化有关。我们检查了在家中和户外度过的时间作为接触空气中 PAH 的预测因素，并测量了马里兰州巴尔的摩 118 名 5-12 岁儿童的尿液 1-羟基芘-葡萄糖醛酸 (1-OHPG) 作为 PAH 的内部剂量。四个季节各一周（周六至周六）：通过问卷调查评估日常活动，监测室内空气尼古丁和PM浓度，并在周二（第3天）和周六（第7天）采集尿液样本进行1-OHPG测量。在非吸烟家庭中度过的时间与尿液中 1-OHPG 浓度显着降低相关（β=− 0.045，95% CI (− 0.076,− 0.013)），而二手烟 (SHS) 暴露改变了这些关联，在吸烟家庭中度过的儿童的尿液 1-OHPG 浓度高于非吸烟家庭中的儿童（交互作用 P 值= 0.012）。仅男孩的户外活动时间与尿 1-OHPG 浓度升高相关（β= 0.097，95% CI（0.037，0.157））。我们的结果表明，二手烟和环境（室外）空气污染会导致内城区儿童体内多环芳烃剂量的增加。
Polycyclic aromatic hydrocarbons (PAHs), the by-products of incomplete combustion of organic materials, are commonly found on particulate matter (PM) and have been associated with the development of asthma and asthma exacerbation in urban populations. We examined time spent in the home and outdoors as predictors of exposures to airborne PAHs and measured urinary 1-hydroxypyrene-glucuronide (1-OHPG) as internal dose of PAHs in 118 children aged 5–12 years from Baltimore, MD. During weeklong periods (Saturday–Saturday) in each of four seasons: daily activities were assessed using questionnaires, indoor air nicotine and PM concentrations were monitored, and urine specimens were collected on Tuesday (day 3) and Saturday (day 7) for measurement of 1-OHPG. Time spent in non-smoking homes was associated with significantly decreased 1-OHPG concentration in urine (β=− 0.045, 95% CI (− 0.076,− 0.013)), and secondhand smoke (SHS) exposures modified these associations, with higher urinary 1-OHPG concentrations in children spending time in smoking homes than non-smoking homes (P-value for interaction= 0.012). Time spent outdoors was associated with increased urinary 1-OHPG concentrations (β= 0.097, 95% CI (0.037, 0.157)) in boys only. Our results suggest that SHS and ambient (outdoor) air pollution contribute to internal dose of PAHs in inner city children.