Lytic Cycle of Toxoplasma gondii: 15 Years Later.
Lytic Cycle of Toxoplasma gondii: 15 Years Later.
复制标题
弓形虫的裂解周期：15年后。
DOI：
10.1146/annurev-micro-091014-104100
复制
发表时间：
2015
影响因子：
10.5
通讯作者：
Gubbels MJ
中科院分区：
文献类型：
--
作者：
Blader IJ;Coleman BI;Chen CT;Gubbels MJ
弓形虫病是由细胞内顶复体寄生虫弓形虫急性感染引起的临床和病理结果。症状是由伴随寄生虫生长的溶解性组织破坏引起的。本文综述了目前对宿主细胞入侵、寄生虫复制和最终排出的理解，以及T。弓形虫操纵宿主细胞以确保存活。自从15年前发表了这篇评论的前一次迭代以来，我们对寄生虫生长和宿主细胞出口机制的分子理解取得了重要进展，寄生虫对宿主的操纵知识也迅速发展。在这里，我们涵盖了分子进展和包括这些主题的当前概念框架，并着眼于15年后可能知道的内容。
Toxoplasmosis is the clinical and pathological consequence of acute infection with the obligate intracellular apicomplexan parasite Toxoplasma gondii. Symptoms result from tissue destruction that accompanies lytic parasite growth. This review updates current understanding of the host cell invasion, parasite replication and eventual egress that comprise the lytic cycle, as well as the ways T. gondii manipulates host cells to assure survival. Since the publication of a previous iteration of this review 15 years ago, important advances have been made in our molecular understanding of parasite growth and mechanisms of host cell egress, and knowledge of the parasite’s manipulation of the host has rapidly progressed. Here we cover molecular advances and current conceptual frameworks that include each of these topics, with an eye to what might be known 15 years from now.