Double C(sp3)-H Bond Functionalization Mediated by Sequential Hydride Shift/Cyclization Process: Diastereoselective Construction of Polyheterocycles
Double C(sp3)-H Bond Functionalization Mediated by Sequential Hydride Shift/Cyclization Process: Diastereoselective Construction of Polyheterocycles
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DOI：
10.1021/ja412706d
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发表时间：
2014-03-12
影响因子：
15
通讯作者：
Akiyama, Takahiko
中科院分区：
文献类型：
--
作者：
Mori, Keiji;Kurihara, Kazuki;Akiyama, Takahiko
本文描述了由连续氢化物移位/环化过程触发的两种新型双C(sp(3))-H键官能化：(1)通过[1,6]-和[1,5]-氢化物移位序列构建双环[3.2.2]壬烷骨架，以及(2)连续[1,4]-和[1,5]-氢化物移位介导的线性三环骨架的构建。
Described herein are two novel types of double C(sp(3))-H bond functionalizations triggered by a sequential hydride shift/cyclization process: (1) construction of a bicyclo[3.2.2]nonane skeleton by a [1,6]- and [1,5]-hydride shift sequence and (2) sequential [1,4]- and [1,5]-hydride shift mediated construction of a linear tricyclic skeleton.