A new accurate, simple formula for LDL-cholesterol estimation based on directly measured blood lipids from a large cohort
A new accurate, simple formula for LDL-cholesterol estimation based on directly measured blood lipids from a large cohort
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DOI：
10.1258/acb.2012.011259
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发表时间：
2013-01-01
影响因子：
2.2
通讯作者：
de Cordova, Mauricio Mendes
中科院分区：
文献类型：
--
作者：
Mendes de Cordova, Caio Mauricio;de Cordova, Mauricio Mendes
背景：低密度脂蛋白胆固醇（LDL-c）是心血管风险评估的主要测量参数。普遍接受的公式（LDL-F）估计LDL-C开发的弗里德瓦尔德和同事在1972年使用的数据从448个人遭受已知的不准确性在极端的甘油三酯（TG）和总胆固醇（TC）value.Methods：我们产生了新的公式的基础上，一个大型的巴西数据库，直接测量的血脂值从10,664禁食的个人。通过LDL-C Select FS（DiaSys）系统（一种无需离心的均相方法）测量该数据库LDL-c。采用线性和非线性方法生成公式，并选择准确度最高、简单易行的公式进行临床应用。（TC - HDL-c）提供了LDL-c的准确估计值，与直接测量的LDL结论：在较宽的TC、HDL-c和TG值范围内，新公式的预测精度优于其它几种LDL-c公式。该公式在其他人群中的验证和应用是必要的。
Background: Low-density lipoprotein cholesterol (LDL-c) is the major measured parameter for cardiovascular risk assessment. The generally accepted formula (LDL-F) for estimating LDL-c developed by Friedewald and colleagues in 1972 using data from 448 individuals suffers from known inaccuracies at extremes of triglyceride (TG) and total cholesterol (TC) values.Methods: We generated new formulas based on a large Brazilian database containing directly measured lipid values from 10,664 fasted individuals. This database LDL-c was measured by the LDL-C Select FS (DiaSys) system, a homogeneous method without centrifugation. The formulas were generated using linear and non-linear approaches, and the formula with the highest accuracy and simplicity for general clinical use was selected.Results: The simple formula LDL-c = 3/4 (TC - HDL-c) provided an accurate estimate of LDL-c, a higher correlation with directly measured LDL (r = 0.93) compared with LDL-F (r = 0.87), and also a higher accuracy.Conclusions: The new formula outperformed several other LDL-c formulas over a wide range of TC, HDL-c and TG values. The validation and application of this formula in other populations is warranted.