Deficient Functioning of Frontostriatal Circuits During the Resolution of Cognitive Conflict in Cannabis-Using Youth
Deficient Functioning of Frontostriatal Circuits During the Resolution of Cognitive Conflict in Cannabis-Using Youth
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DOI：
10.1016/j.jaac.2018.09.436
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发表时间：
2019-07-01
影响因子：
13.3
通讯作者：
Marsh, Rachel
中科院分区：
文献类型：
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作者：
Cyr, Marilyn;Tau, Gregory Z.;Marsh, Rachel
目的：自我调节控制障碍参与成瘾的形成和维持，包括大麻使用障碍。在成年人中，长期使用大麻与在需要进行自我调节控制的任务（包括解决认知冲突）中额纹状体回路的紊乱有关。未充分研究的是这些过程的行为和神经相关的早期大麻使用过程中从长期使用的影响解开。本研究探讨了在解决认知冲突的cannabis-using youth.Method：功能磁共振成像数据采集从28个大麻使用青年和32个年龄匹配的健康参与者在西蒙任务的性能的额叶纹状体电路的功能。一般线性模型被用来比较各组在对冲突刺激做出正确反应时的大脑激活模式。心理生理学的相互作用分析被用来研究冲突相关的额纹状体连接跨组。协会的额纹状体激活和连接与大麻使用measurements explored.Results：减少冲突相关的活动中检测到大麻使用与健康对照青年在额纹状体区域，包括腹内侧前额叶皮层，纹状体，苍白球，丘脑。额纹状体连接没有不同的群体，但腹内侧前额叶皮层和纹状体之间的负连接检测在2 groups.Conclusion：这些研究结果是一致的大麻相关的干扰在成年人的额纹状体电路以前的报告，并指出大麻对青年神经发育变化的具体影响。未来的研究应该检查额纹状体功能是否是大麻使用障碍严重程度的可靠标志，以及基于回路的干预措施的潜在目标。
Objective: Disturbances in self-regulatory control are involved in the initiation and maintenance of addiction, including cannabis use disorder. In adults, long-term cannabis use is associated with disturbances in frontostriatal circuits during tasks that require the engagement of self-regulatory control, including the resolution of cognitive conflict. Understudied are the behavioral and neural correlates of these processes earlier in the course of cannabis use disentangled from effects of long-term use. The present study investigated the functioning of frontostriatal circuits during the resolution of cognitive conflict in cannabis-using youth.Method: Functional magnetic resonance imaging data were acquired from 28 cannabis-using youth and 32 age-matched healthy participants during the performance of a Simon task. General linear modeling was used to compare patterns of brain activation during correct responses to conflict stimuli across groups. Psychophysiologic interaction analyses were used to examine conflict-related frontostriatal connectivity across groups. Associations of frontostriatal activation and connectivity with cannabis use measures were explored.Results: Decreased conflict-related activity was detected in cannabis-using versus healthy control youth in frontostriatal regions, including the ventromedial prefrontal cortex, striatum, pallidum, and thalamus. Frontostriatal connectivity did not differ across groups, but negative connectivity between the ventromedial prefrontal cortex and striatum was detected in the 2 groups.Conclusion: These findings are consistent with previous reports of cannabis-associated disturbances in frontostriatal circuits in adults and point to the specific influence of cannabis on neurodevelopmental changes in youth. Future studies should examine whether frontostriatal functioning is a reliable marker of cannabis use disorder severity and a potential target for circuit-based interventions.